Study of mechanism of carcinogenesis by 1,2-dichloropropane using animal experiment model
Project/Area Number |
26340042
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Risk sciences of radiation and chemicals
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Research Institution | Osaka City University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
魏 民 大阪市立大学, 大学院医学研究科, 准教授 (70336783)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 1,2-ジクロロプロパン / 動物実験モデル / 発がん性 / 二段階発がん / 環境 / 癌 / 病理学 / プロテオーム / ゲノム |
Outline of Final Research Achievements |
In this study, 1,2-dichloropropane (1,2-DCP) and toxicity were investigated using an animal experiment model. As a result, bile duct carcinogenicity was not observed in mouse, rat and hamster in animal test with single exposure of 1,2-DCP and DCM. However, co-exposures of 1,2-DCP and DCM revealed a stronger liver carcinogenic potential compared to single exposure to 1,2-DCP. In addition, it was suggested that as a mechanism of tumor development, a variety of signaling pathways are activated by increased expression of cell proliferation-related factors.
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Report
(4 results)
Research Products
(99 results)
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[Journal Article] Carbonic anhydrase 2 is a novel invasion-associated factor in urinary bladder cancers.2017
Author(s)
Tachibana H, Gi M, Kato M, Yamano S, Fujioka M, Kakehashi A, Hirayama Y, Koyama Y, Tamada S, Nakatani T, Wanibuchi H.
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Journal Title
Cancer Sci
Volume: 108
Issue: 3
Pages: 331-337
DOI
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Peer Reviewed / Open Access
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[Journal Article] Granular C3 Dermatosis.2016
Author(s)
Hashimoto T, Tsuruta D, Yasukochi A, Imanishi H, Sekine H, Fujita T, Wanibuchi H, Gi M, Kárpáti S, Sitaru C, Zone JJ, Endo D, Abe S, Nishino T, Koji T, Ishii N.
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Journal Title
Acta Derm Venereol
Volume: 00
Pages: 00-00
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Alteration of Esophageal Microbiome by Antibiotic Treatment Does Not Affect Incidence of Rat Esophageal Adenocarcinoma.2016
Author(s)
Sawada A, Fujiwara Y, Nagami Y, Tanaka F, Yamagami H, Tanigawa T, Shiba M, Tominaga K, Watanabe T, Gi M, Wanibuchi H, Arakawa T.
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Journal Title
Dig Dis Sci
Volume: 61
Pages: 3161-3168
Related Report
Peer Reviewed / Open Access
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[Journal Article] The role of deltaNp63pos CD44vpos cells in the development of NTCU-induced peripheral type of mouse lung squamous cell carcinomas..2016
Author(s)
Yamano S, Gi M, Tago Y, Doi K, Okada S, Hirayama S, Tachibana H, Ishii N, Fujioka M, Tatsumi K,Wanibuchi H.
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Journal Title
Cancer Sci
Volume: 107
Issue: 2
Pages: 123-132
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway.2016
Author(s)
Inaba H, Goto H, Kasahara K, Kumamoto K, Yonemura S, Inoko A, Yamano S, Wanibuchi H, He D, Goshima N, Kiyono T, Hirotsune S, Inagaki M.
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Journal Title
J Cell Biol.
Volume: 212
Issue: 4
Pages: 409-423
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Modifying effects of 1,2-dichloropropane on N-nitrosobis(2-oxopropyl)amine-induced cholangiocarcinogenesis in male Syrian hamsters2015
Author(s)
Gi M, Fujioka M, Yamano S, Shimomura E, Kanki M, Kawachi S, Tachibana H, Tatsumi K, Fang H, Ishii N, Kakehashi A, Wanibuchi H.
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Journal Title
The Journal of Toxicological Sciences
Volume: 40
Issue: 5
Pages: 647-656
DOI
NAID
ISSN
0388-1350, 1880-3989
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Gene-modified embryonic stem cell test to characterize chemical risks.2015
Author(s)
Kitada K, Kizu A, Teramura T, Takehara T, Hayashi M, Tachibana D, Wanibuchi H, Fukushima S, Koyama M, Yoshida K, Morita T.
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Journal Title
Environ Sci Pollut Res Int.
Volume: 22
Issue: 22
Pages: 18252-18259
DOI
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Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Hsc70 contributes to cancer cell survival by preventing Rab1A degradation under stress conditions.2014
Author(s)
Tanaka M, Mun S, Harada A, Ohkawa Y, Inagaki A, Sano S, Takahashi K, Izumi Y, Osada-Oka M, Wanibuchi H, Yamagata M, Yukimura T, Miura K, Shiota M, Iwao H.
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Journal Title
PLoS One
Volume: 9
Issue: 5
Pages: e96785-e96785
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Establishment of neutralizing rat monoclonal antibodies for fibroblast growth factor-22014
Author(s)
Tanaka M, Yamaguchi M, Shiota M, Kawamoto Y, Takahashi K, Inagaki A, Osada-Oka M, Harada A, Wanibuchi H, Izumi Y, Miura K, Iwao H, Ohkawa Y.
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Journal Title
Monoclon Antib Immunodiagn Immunother
Volume: 33
Issue: 4
Pages: 261-269
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Comparative proteomics analysis of gastric cancer stem cells2014
Author(s)
Morisaki T, Yashiro M, Kakehashi A, Inagaki A, Kinoshita H, Fukuoka T, Kasashima H, Masuda G, Sakurai K, Kubo N, Muguruma K, Ohira M, Wanibuchi H, Hirakawa K.
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Journal Title
PLoS One
Volume: 9
Issue: 11
Pages: e110736-e110736
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] ヒ素の発がん機序の解明2014
Author(s)
鰐渕英機、魏 民
Organizer
第60回日本病理学会秋期特別総会
Place of Presentation
国立劇場おきなわ(沖縄県・浦添市)
Year and Date
2014-11-20
Related Report
Invited
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