| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Vitamin A reduces fat mass and can contribute to the prevention of obesity. In the present study, we investigated how vitamin A reduced fat mass in a high fat-diet (HFD)-induced obese mouse model. The vitamin A-treated HFD mice (VA mice) had a significant reduction in body weight and fat mass. The energy expenditure in the VA mice significantly increased with the activation of AMP-activated protein kinase α (AMPKα) in the white adipose tissue (WAT). However, the intake of vitamin A caused some typical hypervitaminosis A. We suggest that excess intake of vitamin A reduces the fat mass in HFD-induced obese mice through enhancement of energy expenditure by activation of AMPKα in the WAT.
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