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Study on reverse cholesterol transport via small intestine by polyphenol

Research Project

Project/Area Number 26350139
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionNihon University (2015-2016)
National Defense Medical College (2014)

Principal Investigator

KONDO Harumi  日本大学, 生物資源科学部, 講師 (80401602)

Co-Investigator(Kenkyū-buntansha) 池脇 克則  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 内科学, 教授 (40287199)
綾織 誠人  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 病院, 助教 (70532464)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsコレステロール / ポリフェノール / 動脈硬化 / HDL / クルクミン / HDL
Outline of Final Research Achievements

Recently, we have revealed that the cholesterol absorption inhibitor ezetimibe promoted reverse cholesterol transport (RCT) in hamsters.Some polyphenols have reported to enhance cholesterol efflux from macrophages. Several papers reported that curcumin and qercetin inhibited cholesterol absorption in vitro, it remains unclear whether it affects RCT functions. Therefore, we examined whether administration of curcumin or quercetin to hamsters fed a high cholesterol diet regulates RCT from macrophages, but they did not increase RCT.In conclution, curcumin and quercetin did not affect the inhibition of cholesterol absorption and enhance RCT from the macrophages under the condition of our study.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2015

All Book (1 results)

  • [Book] クルクミンによるコレステロール吸収抑制排出作用に関する研究2015

    • Author(s)
      浦上財団報告書
    • Total Pages
      9
    • Publisher
      公益財団法人 浦上食品食文化振興財団
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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