Study on reverse cholesterol transport via small intestine by polyphenol

Research Project

Project/Area Number	26350139
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Eating habits
Research Institution	Nihon University (2015-2016) National Defense Medical College (2014)
Principal Investigator	KONDO Harumi 日本大学, 生物資源科学部, 講師 (80401602)
Co-Investigator(Kenkyū-buntansha)	池脇克則防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 内科学, 教授 (40287199) 綾織誠人防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 病院, 助教 (70532464)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords	コレステロール / ポリフェノール / 動脈硬化 / ＨＤＬ / クルクミン / HDL
Outline of Final Research Achievements	Recently, we have revealed that the cholesterol absorption inhibitor ezetimibe promoted reverse cholesterol transport (RCT) in hamsters.Some polyphenols have reported to enhance cholesterol efflux from macrophages. Several papers reported that curcumin and qercetin inhibited cholesterol absorption in vitro, it remains unclear whether it affects RCT functions. Therefore, we examined whether administration of curcumin or quercetin to hamsters fed a high cholesterol diet regulates RCT from macrophages, but they did not increase RCT.In conclution, curcumin and quercetin did not affect the inhibition of cholesterol absorption and enhance RCT from the macrophages under the condition of our study.