| Project/Area Number |
26350148
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Nagasaki University |
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Principal Investigator |
HIRASAKA Katsuya 長崎大学, 水産・環境科学総合研究科(水産), 助教 (70432747)
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| Co-Investigator(Kenkyū-buntansha) |
二川 健 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (20263824)
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| Co-Investigator(Renkei-kenkyūsha) |
TACHIBANA Katsuyasu 長崎大学, 水産・環境科学総合研究科(水産), 教授 (20171712)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 保健機能食品 / マリンフラボノイド / 加齢 / 筋萎縮 / ユビキチンリガーゼ |
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| Outline of Final Research Achievements |
In this study, we found flavonoid, morin in brown algae. Next, we examined the effect of dietary marine flavonoid containing morin, on the wasting of muscle. The wet weight and myofiber size of skeletal muscle in tumor-bearing mice, which is known to muscle atrophy model, significantly decreased, compared with that of vehicle-injected control mice. In contrast, the wet weight and myofiber size of skeletal muscle in tumor-bearing mice fed the marine flavonoid diet were nearly the same as those in vehicle-injected control mice. Moreover, treatment of marine flavonoid in C2C12 myotube inhibited myotube atrophy induced by tumor. These results suggest that dietary marine flavonoid suppresses muscle wasting in tumor-bearing mice. Thus, marine flavonoid may be efficacious in a therapeutic approach against the wasting of muscle.
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