Effect of functional marine flavonoid on muscle atrophy
Project/Area Number |
26350148
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Eating habits
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Research Institution | Nagasaki University |
Principal Investigator |
HIRASAKA Katsuya 長崎大学, 水産・環境科学総合研究科(水産), 助教 (70432747)
|
Co-Investigator(Kenkyū-buntansha) |
二川 健 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (20263824)
|
Co-Investigator(Renkei-kenkyūsha) |
TACHIBANA Katsuyasu 長崎大学, 水産・環境科学総合研究科(水産), 教授 (20171712)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 保健機能食品 / マリンフラボノイド / 加齢 / 筋萎縮 / ユビキチンリガーゼ |
Outline of Final Research Achievements |
In this study, we found flavonoid, morin in brown algae. Next, we examined the effect of dietary marine flavonoid containing morin, on the wasting of muscle. The wet weight and myofiber size of skeletal muscle in tumor-bearing mice, which is known to muscle atrophy model, significantly decreased, compared with that of vehicle-injected control mice. In contrast, the wet weight and myofiber size of skeletal muscle in tumor-bearing mice fed the marine flavonoid diet were nearly the same as those in vehicle-injected control mice. Moreover, treatment of marine flavonoid in C2C12 myotube inhibited myotube atrophy induced by tumor. These results suggest that dietary marine flavonoid suppresses muscle wasting in tumor-bearing mice. Thus, marine flavonoid may be efficacious in a therapeutic approach against the wasting of muscle.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Dietary Supplementation with Isoflavones Prevents Muscle Wasting in Tumor-Bearing Mice2016
Author(s)
Hirasaka K*, Saito S, Yamaguchi S, Miyazaki R, Wang Y, Haruna M, Taniyama S, Higashitani A, Terao J, Nikawa T, Tachibana K
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Journal Title
J Nutr Sci Vitaminol
Volume: 62
Issue: 3
Pages: 178-184
DOI
NAID
ISSN
0301-4800, 1881-7742
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Preventive effect of dietary quercetin on disuse muscle atrophy by targeting mitochondria in denervated mice.2016
Author(s)
Mukai R, Matsui N, Fujikura Y, Matsumoto N, Hou DX, Kanzaki N, Shibata H, Horikawa M, Iwasa K, Hirasaka K, Nikawa T, Terao J
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Journal Title
J Nutr Biochem
Volume: 31
Pages: 67-76
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Capric Acid Up-Regulates UCP3 Expression without PDK4 Induction in Mouse C2C12 Myotubes2016
Author(s)
Abe T, Hirasaka K, Kohno S, Tomida C, Haruna M, Uchida T, Ohno A, Oarada M, Teshima-Kondo S, Okumura Y, Choi I, Aoyama T, Terao J, Nikawa T*.
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Journal Title
J Nutr Sci Vitaminol
Volume: 62
Issue: 1
Pages: 32-39
DOI
NAID
ISSN
0301-4800, 1881-7742
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Anti-obesity effects of enzymatically-digested alginate oligomer in mice model fed a high-fat-diet.2016
Author(s)
Satoru Nakazono, Kichul Cho, Shogo Isaka, Ryogo Abu, Takeshi Yokose, Masakazu Murata, Mikinori Ueno, Katsuyasu Tachibana, Katsuya Hirasaka, Daekyung Kim, Tatsuya Oda
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Journal Title
Bioactive Carbohydrates and Dietary Fibre
Volume: 7
Pages: 1-8
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] UCP3 is associated with Hax-1 in mitochondria in the presence of calcium ion.2016
Author(s)
Hirasaka K., Mills E. M., Haruna M., Bando A., Ikeda C., Abe T., Kohno S., Nowinski S. M., Lago C. U., Akagi K., Tochio H., Ohno A., Teshima-Kondo S., Okumura Y., Nikawa T.
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Journal Title
Biochem Biophys Res Commun.
Volume: 472
Pages: 108-113
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Structural analysis of the TKB domain of ubiquitin ligase Cbl-b complexed with its small inhibitory peptide, Cblin.2016
Author(s)
Ohno A. Ochi A., Maita N., Ueji. T., Bando A., Nakao R., Hirasaka K., Abe T., Teshima-Kondo S., Nemoto H., Okumura Y., Higashibata A., Yano S., Tochio H., Nikawa T
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Journal Title
Arch. Biochem. Biophys
Volume: 594
Pages: 1-7
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The malignant progression effects of regorafenib in human colon cancer cells2016
Author(s)
Tomida C, Aibara K, Yamagishi N, Yano C, Nagano H, Abe T, Ohno A, Hirasaka K, Nikawa T, Teshima-Kondo S
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Journal Title
J. Med. Invest.
Volume: 62
Issue: 3.4
Pages: 195-198
DOI
NAID
ISSN
1343-1420, 1349-6867
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] A novel myogenic function residing in the 5’ non-coding region of Insulin receptor substrate-1 (Irs-1) transcript2015
Author(s)
Nagano H, Yamagishi N, Tomida C, Yano C, Aibara K, Kohno S, Abe T, Ohno A, Hirasaka K, Okumura Y, Mills EM, Nikawa T, Teshima-Kondo S.
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Journal Title
BMC Cell Biol.
Volume: in press
Pages: 1-10
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Effects of dietary soy protein on skeletal muscle volume and strength in humans with various physical activities2015
Author(s)
Hashimoto R, Sakai A, Murayama M, Ochi A, Abe T, Hirasaka K, Ohno A, Teshima-Kondo S, Yanagawa H, Yasui N, Inatsugi M, Doi D, Takeda M, Mukai R, Terao J, Nikawa T
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Journal Title
J. Med. Invest.
Volume: 62
Issue: 3.4
Pages: 177-183
DOI
NAID
ISSN
1343-1420, 1349-6867
Related Report
Peer Reviewed / Open Access
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[Journal Article] Prevention of skeletal muscle atrophy in vitro using anti-ubiquitination oligopeptide carried by atelocollagen.2015
Author(s)
Kawai N, Hirasaka K, Maeda T, Haruna M, Shiota C, Ochi A, Abe T, Kohno S, Ohno A, Teshima-Kondo S Mori H, Tanaka E, Nikawa T
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Journal Title
BBA - Molecular Cell Research
Volume: 1853
Pages: 873-880
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] N-myristoylated ubiquitin ligase Cbl-b inhibitor prevents on glucocorticoid-induced atrophy in mouse skeletal muscle.2015
Author(s)
Ochi A, Abe T, Nakao R, Yamamoto Y, Kitahata K, Takagi M, Hirasaka K, Ohno A, Teshima-Kondo S, Taesik G, Choi I, Kawamura T, Nemoto H, Mukai R, Terao J, Nikawa T.
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Journal Title
Arch Biochem Biophys
Volume: 570
Pages: 23-31
DOI
Related Report
Peer Reviewed
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[Journal Article] Chronic exposure of VEGF inhibitors promotes the malignant phenotype of colorectal cancer cells2015
Author(s)
Tomida C, Yamagishi N, Aibara K, Yano C, Uchida T, Abe T, Ohno A, Hirasaka K, Nikawa T, Teshima-Kondo S.
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Journal Title
J. Med. Invest.
Volume: 62
Issue: 1.2
Pages: 75-79
DOI
NAID
ISSN
1343-1420, 1349-6867
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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