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A study of practical suppression method of hazardous heartbeat generations using both numerical and animal models

Research Project

Project/Area Number 26350508
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionTokyo Metropolitan University

Principal Investigator

Yazawa Toru  首都大学東京, 理工学研究科, 客員研究員 (30106603)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords不整脈 / 死の予兆 / DFA / 心拍 / 危険脈
Outline of Final Research Achievements

We used both animal models and numerical models. An increase of extracellular potassium ions ([K]o) was a key cause for the generation of alternans heartbeat. We found an extremely beautiful relationship between [K]o and the permeability of sodium channels (GNa): a parabolic relationship between normal heartbeat area and abnormal heartbeat area in a parameter plane. In medicine, control of K ions and Na ions must suppress ill state of the heart, i.e., alternans state.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (41 results)

All 2017 2016 2015 2014

All Journal Article (9 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 9 results,  Open Access: 7 results,  Acknowledgement Compliant: 7 results) Presentation (27 results) (of which Int'l Joint Research: 10 results,  Invited: 12 results) Book (3 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Invisible Emotion, Anxiety and Fear: Quantifying the Mind Using EKG with mDFA.2017

    • Author(s)
      T. Yazawa
    • Journal Title

      Multi-Conference on Complexity, Informatics and Cybernetics (IMCIC 2017), Proceedings

      Volume: 1 Pages: 201-205

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Quantification of stress: a case study using modified detrended fluctuation analysis (mDFA) of the heartbeat.2016

    • Author(s)
      T. Yazawa
    • Journal Title

      WMSCI 2016, Proceedings

      Volume: 1 Pages: 121-125

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Alternans generation in the crustacean heart model: a simulation-electrophysiology study.2016

    • Author(s)
      T. Yazawa and H. Kitajima
    • Journal Title

      NOLTA2016, Proceedings

      Volume: 1 Pages: 322-325

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Monitoring Heart Health and Structural Health: mDFA Quantification.2016

    • Author(s)
      Yazawa, T.
    • Journal Title

      Proceedings of IMCIC 2016

      Volume: 1 Pages: 5-5

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Quantifying Stress Using mDFA:Heartbeats Exhibit Stress/Fear/Anxiety in Animal Model and Humans.2015

    • Author(s)
      Yazawa, T.
    • Journal Title

      Journal on Systemics, Cybernetics and Informatics

      Volume: Volume 13 - Number 4 Pages: 82-84

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Everyday Life Quantification Using mDFA: Heart Health Monitoring and Structural Health Monitoring.2015

    • Author(s)
      Yazawa, T.
    • Journal Title

      Proceedings of the ASME 2015 International Design Engineering Technical Conferences & Computers and Information in Engineering Conference IDETC/CIE 2015

      Volume: 1 Pages: 6-6

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Quantifying Stress Using Modified DFA (mDFA): A Practical Heartbeat-Interval Time Series Analysis.2015

    • Author(s)
      Yazawa, T. and Wakabayashi, M.
    • Journal Title

      Proceedings of The World Congress on Engineering and Computer Science 2015

      Volume: 1 Pages: 529-535

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Quantifying Stress Using mDFA of Heartbeats.2015

    • Author(s)
      Yazawa, T.
    • Journal Title

      IMCIC-2015

      Volume: Vol. 1 Pages: 178-180

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Alternans in a mathematical crustacean cardiac model.2015

    • Author(s)
      Tarumoto, T., Yazawa, T., Kitajima, H.
    • Journal Title

      NCSP'15

      Volume: 1 Pages: 611-614

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Invisible Emotion, Anxiety and Fear: Quantifying the Mind Using EKG with mDFA.2017

    • Author(s)
      T. Yazawa
    • Organizer
      The 8th International Multi-Conference on Complexity, Informatics and Cybernetics (IMCIC 2017)
    • Place of Presentation
      Orlando, Florida, USA
    • Year and Date
      2017-03-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 「mDFAの実用化」2017

    • Author(s)
      矢澤徹
    • Organizer
      「mDFA」技術指導会
    • Place of Presentation
      本田技術研究所 四輪R&Dセンター HGT会議室 宇都宮市
    • Year and Date
      2017-03-07
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 心拍リズムとストレス -カニの心臓・ヒトの心臓-2017

    • Author(s)
      矢澤徹
    • Organizer
      mDFA講演会
    • Place of Presentation
      北海道教育大学旭川校 芝木邦也教授  第2会議室 旭川市
    • Year and Date
      2017-03-02
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 心拍ゆらぎ解析mDFA:突然死・自然死・ストレスの可視化2017

    • Author(s)
      矢澤徹
    • Organizer
      mDFA講演会
    • Place of Presentation
      高松市、北島博之教授 香川大学 工学部 電子・情報工学科 電子情報通信コース
    • Year and Date
      2017-01-11
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 「mDFA」2016

    • Author(s)
      矢澤徹
    • Organizer
      「mDFA」技術相談会
    • Place of Presentation
      本田技術研究所 四輪R&Dセンター HGT会議室 宇都宮市
    • Year and Date
      2016-12-25
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] あたらしい心拍ゆらぎ解析mDFA:突然死・自然死・ストレスの可視化:振動運動ならなんでも定量判定2016

    • Author(s)
      矢澤徹
    • Organizer
      mDFA講演会
    • Place of Presentation
      長崎国際大学 薬学部会議室 和田守正教授
    • Year and Date
      2016-12-07
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Alternans generation in the crustacean heart model: a simulation-electrophysiology study.2016

    • Author(s)
      T. Yazawa
    • Organizer
      International Symposium on Nonlinear Theory and Its Applications, NOLTA2016
    • Place of Presentation
      Yugawara, Japan
    • Year and Date
      2016-11-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Quantifying stress through crustacean EKG: A modified detrended fluctuation analysis(mDFA) of the nerve-heart dynamics.2016

    • Author(s)
      T. Yazawa
    • Organizer
      Neuroscience 2016, Society for Neuroscience
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] mDFAの原理2016

    • Author(s)
      矢澤徹
    • Organizer
      mDFA講演会
    • Place of Presentation
      首都大学東京 心理学 6号館208教室 石原正規准教授 八王子市南大沢
    • Year and Date
      2016-10-19
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 心拍ゆらぎ解析法による突然死・自然死・ストレスの可視化:カニとヒトの神経生物学2016

    • Author(s)
      矢澤徹
    • Organizer
      mDFA講演会
    • Place of Presentation
      長崎大学環境学部 会議室、岡田二郎教授
    • Year and Date
      2016-09-16
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 心拍ゆらぎ解析法による突然死・自然死・ストレスの可視化:カニとヒトの神経生物学2016

    • Author(s)
      矢澤徹
    • Organizer
      mDFA講演会
    • Place of Presentation
      九州大学理学部OB研究会 森俊憲医師 (小児科)福岡リーセントホテル 小会議室 福岡市
    • Year and Date
      2016-08-20
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Quantifying Stress Using mDFA : An Empirical Study for a Practical Method of Heartbeat Analysis.2016

    • Author(s)
      T. Yazawa
    • Organizer
      Society for Chaos Theory in Psychology & Life Sciences (SCTPLS) 26th Annual International Conference
    • Place of Presentation
      University of Utah, Salt Lake City UT, USA
    • Year and Date
      2016-07-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Quantification of stress: a case study using modified detrended fluctuation analysis (mDFA) of the heartbeat2016

    • Author(s)
      矢澤徹
    • Organizer
      mDFA講演会
    • Place of Presentation
      北海道教育大学 芝木邦也教授 (科学教育、森林学、木質学)同大学事務局第1会議室 札幌市
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Quantification of stress: a case study using modified detrended fluctuation analysis (mDFA) of the heartbeat.2016

    • Author(s)
      T. Yazawa
    • Organizer
      The 20th World Multi-Conference on Systemics, Cybernetics and Informatics: WMSCI 2016
    • Place of Presentation
      Orlando, Florida, USA
    • Year and Date
      2016-07-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] カニの心臓からヒトの心臓へ:神経による心拍調節2016

    • Author(s)
      矢澤徹
    • Organizer
      mDFA講演会
    • Place of Presentation
      日本女子大学 田邉和子教授(歴史言語学)、図書館会議室
    • Year and Date
      2016-07-04
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] カニの心臓からヒトの心臓へ:神経による心拍調節2016

    • Author(s)
      矢澤徹
    • Organizer
      mDFA講演会
    • Place of Presentation
      日本大学文理学部  斎藤稔教授 物理生命システム
    • Year and Date
      2016-05-12
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Monitoring Heart Health and Structural Health: mDFA Quantification2016

    • Author(s)
      Yazawa, T.
    • Organizer
      The 7th International Multi-Conference on Complexity, Informatics and Cybernetics: IMCIC 2016, ICT Applications in Health Care and Bio-Medical ICT (IMCIC)
    • Place of Presentation
      Orlando, Florida, USA.
    • Year and Date
      2016-03-09
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Quantifying Stress Using Modified DFA (mDFA): A Practical Heartbeat-Interval Time Series Analysis.2015

    • Author(s)
      Yazawa, T. and Wakabayashi, M.
    • Organizer
      WCECS 2015
    • Place of Presentation
      UCバークレー、サンフランシスコ、USA.
    • Year and Date
      2015-10-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Quantification Of Stress/Anxiety/Fear: Modified Detrended Fluctuation Analysis Of Heartbeats, From Crustacean Model Animals To Humans.2015

    • Author(s)
      Yazawa, T.
    • Organizer
      Society for neuroscience
    • Place of Presentation
      シカゴ, USA.
    • Year and Date
      2015-10-19
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] ストレスや緊張を数値判定する心拍ゆらぎ解析法の開発2015

    • Author(s)
      矢澤徹.
    • Organizer
      イノベーションジャパン
    • Place of Presentation
      東京ビックサイト、東京.
    • Year and Date
      2015-08-27
    • Related Report
      2015 Research-status Report
  • [Presentation] Everyday Life Quantification Using mDFA: Heart Health Monitoring and Structural Health Monitoring.2015

    • Author(s)
      Yazawa, T.
    • Organizer
      IDETC 2015, American Society of Mechanical Engneers
    • Place of Presentation
      ボストン, USA.
    • Year and Date
      2015-08-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Quantifying Stress Using mDFA: Heartbeats Exhibit Stress/Fear/Anxiety in Animal Model and Humans2015

    • Author(s)
      Yazawa, T.
    • Organizer
      WMSCIC 2015, Bio- and Medical Informatics and Cybernetics
    • Place of Presentation
      Orlando, Florida, USA.
    • Year and Date
      2015-07-13
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Quantifying Stress Using mDFA of Heartbeats2015

    • Author(s)
      Yazawa, T.
    • Organizer
      IMCIC-2015
    • Place of Presentation
      Orlando, FL, USA.
    • Year and Date
      2015-03-13
    • Related Report
      2014 Research-status Report
  • [Presentation] A stress-quantification gadget: Detrended fluctuation analysis of heartbeats, from crustacean animal models to humans.2014

    • Author(s)
      Yazawa, T.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington DC, USA.
    • Year and Date
      2014-11-15
    • Related Report
      2014 Research-status Report
  • [Presentation] A stress-quantification gadget: mDFA of heartbeats, from crustacean animal models to humans.2014

    • Author(s)
      Yazawa, T.
    • Organizer
      SCTPLS
    • Place of Presentation
      Milwaukee, Wisconsin, USA
    • Year and Date
      2014-07-31 – 2014-08-02
    • Related Report
      2014 Research-status Report
  • [Presentation] Neurobiology of alternans arrhythmia: A simulation study of the heart of animal models.2014

    • Author(s)
      Yazawa, T. and Kitajima, H.
    • Organizer
      NWP-1
    • Place of Presentation
      Nizhny Novgorod, Russia
    • Year and Date
      2014-07-17 – 2014-07-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Quantification of stress by detrended fluctuation analysis of heartbeats, both in the lobsters and humans.2014

    • Author(s)
      Yazawa, T.
    • Organizer
      NWP-1
    • Place of Presentation
      Nizhny Novgorod, Russia.
    • Year and Date
      2014-07-17 – 2014-07-23
    • Related Report
      2014 Research-status Report
    • Invited
  • [Book] Modified Detrended Fluctuation Analysis (mDFA).2015

    • Author(s)
      Yazawa, T.
    • Total Pages
      98
    • Publisher
      ASME出版(米国機械学会出版)
    • Related Report
      2015 Research-status Report
  • [Book] ゆらぎ解析のための改変DFA法2015

    • Author(s)
      矢澤 徹.
    • Total Pages
      108
    • Publisher
      株式会社めるくまーる
    • Related Report
      2015 Research-status Report
  • [Book] Advances in Bioengineering, Ed, PA Serra. 第13章 Quantifying Stress in Crabs and Humans using Modified DFA2015

    • Author(s)
      Yazawa, T.
    • Total Pages
      23
    • Publisher
      Intech
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 信号解析システム、方法およびプログラム2015

    • Inventor(s)
      矢澤 徹
    • Industrial Property Rights Holder
      首大、株シンフォディアフィル、株三機コンシス
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-02-09
    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] 生体信号解析システム、方法およびプログラム2015

    • Inventor(s)
      矢澤 徹
    • Industrial Property Rights Holder
      首大、株シンフォディアフィル、DVx株
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-03-10
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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