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The study of circulating microRNA removal using apheresis

Research Project

Project/Area Number 26350514
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionJuntendo University

Principal Investigator

KUSAOI Makio  順天堂大学, 医学部, 助教 (80534916)

Co-Investigator(Renkei-kenkyūsha) YAMAJI Ken  順天堂大学, 医学部, 先任准教授 (30327853)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsmicroRNA / circulating microRNA / アフェレシス / 全身性エリテマトーデス / 血漿吸着療法 / 血漿交換療法 / circulatin microRNA
Outline of Final Research Achievements

MicroRNAs are important inhibitors of mRNA translation, participate in differentiation, migration, cell proliferation, and cell death. We examined whether the removal or reduction of circulating miRNAs with apheresis for systemic lupus erythematosus patients using a microRNA array chip. We present the first report that circulating miRNAs in peripheral blood can be separated and possibly directly removed using membrane separation apheresis. Furthermore, it was presumed that the separation rate of microRNAs may depend on the size of microRNAs carrier in the peripheral blood such as exosomes and microparticles.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report

Research Products

(3 results)

All 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results)

  • [Journal Article] Separation of Circulating MicroRNAs Using Apheresis in Patients With Systemic Lupus Erythematosus.2016

    • Author(s)
      Kusaoi M, Yamaji K, Ishibe Y, et al.
    • Journal Title

      Therapeutic Apheresis and Dialysis

      Volume: 20 Pages: 348-353

    • DOI

      10.1111/1744-9987.12471

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 全身性エリテマトーデス患者5名のcirculating microRNAプロファイルとその血漿交換療法による膜分離除去の可否2016

    • Author(s)
      草生 真規雄, 石部 祐介, 塚原 隆伊, ら
    • Organizer
      第60回日本リウマチ学会総会・学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-04-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] 末梢血circulating microRNAは膜分離型アフェレシスにより血漿中から分離される2015

    • Author(s)
      草生 真規雄
    • Organizer
      第53会日本人工臓器学会大会
    • Place of Presentation
      東京ドームホテル
    • Year and Date
      2015-11-21
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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