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Clinicall application of laser blood flow image information measurement technology to diagnose and predict arteriosclerosis

Research Project

Project/Area Number 26350523
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionNational Institute of Technology, Toyama College

Principal Investigator

Hachiga Tadashi  富山高等専門学校, 商船学科, 教授 (80123305)

Co-Investigator(Kenkyū-buntansha) 寺西 恒宣  富山高等専門学校, 機械システム工学科, 教授 (20141880)
安東 嗣修  富山大学, 大学院医学薬学研究部(薬学), 准教授 (50333498)
清水 忠道  富山大学, 大学院医学薬学研究部(医学), 教授 (70260396)
高田 洋吾  大阪市立大学, 大学院工学研究科, 教授 (70295682)
石田 弘樹  岡山理科大学, 理学部, 准教授 (50413761)
秋口 俊輔  富山高等専門学校, 電子情報工学科, 准教授 (50462130)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords血流速度 / in-vivo計測 / 血管血流画像計測 / 血流速分布 / LDV / 多点同時計測 / 血流画像計測 / 血管血流分布画像 / イメージング / 診断技術 / 血流関連疾患 / 流速分布 / 線計測 / 面計測 / in-vivo 計測 / 非侵襲計測 / 動脈硬化 / 血管血流情報 / CFD解析
Outline of Final Research Achievements

The developed L-MLDV system can realize velocity distribution imaging of the carotid artery in a living mouse by means of traverse laser light. We subsequently developed a cross-sectional multiple-point laser Doppler velocimetry (CS-MLDV) system, which can measure the instantaneous two-dimensional flow velocity. An instantaneous 2D velocity distribution can be obtained even for the case of flowing blood. We carried out in-vivo measurement in a mesenteric vessel of a mouse in order to demonstrate the potential of the CS-MLDV. The instantaneous velocity distribution in the flow channel around the obstruction was measured using the MLDV system. Velocity distribution images were obtained by scanning the rectangular flow channel. We attempted to perform non-invasive breast cancer imaging using a MLDV system to monitor blood flow. The validity of the MLDV results was verified through comparison with the results of a computational fluid dynamics (CFD) analysis.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (18 results)

All 2017 2016 2015 2014

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Acknowledgement Compliant: 5 results,  Open Access: 1 results) Presentation (12 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Examining the Relationship between Blood Flow Velocity and Movement of Erythrocytes in a Capillary using Laser Doppler Velocimetry2016

    • Author(s)
      S. Akiguchi, H. Ishida, Y. Takada, T. Teranishi, T. Andoh and T. Hachiga
    • Journal Title

      IEEJ Transactions on Electrical and Electronic Engineering

      Volume: 11 Issue: 4 Pages: 451-456

    • DOI

      10.1002/tee.22262

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] In vivo visualization method by absolute blood flow velocity based on speckle and fringe pattern using two-beam multipoint laser Doppler velocimetry2016

    • Author(s)
      T.Kyoden, N.Shoji, S.Akiguchi, H.Ishida, Y.Takada, N.Momose, T.Homae and T.Hachiga
    • Journal Title

      Journal of Allied Physics

      Volume: 120 Issue: 8

    • DOI

      10.1063/1.4961611

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] High-resolution in-situ LDV monitoring system for measuring velocity distribution in blood vessel2015

    • Author(s)
      T.Kyoden, S.Abe, H.Ishida,S.Akiguchi, T.Andoh,Y.Takada, T.Teranishi, T.Hachiga
    • Journal Title

      Optics Communications

      Volume: 353 Pages: 122-132

    • DOI

      10.1016/j.optcom.2015.04.075

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Observation of tumor microvessels that are controlled by blood flow in breast cancer2015

    • Author(s)
      H. Ishida, T. Andoh, S. Akiguchi, T. Kyoden and T. Hachiga
    • Journal Title

      Applied Physics Letters

      Volume: 106 Issue: 17

    • DOI

      10.1063/1.4919103

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Multi-channel LDV measurement technique using a two-dimensional optical fiber array for obtaining instantaneous velocity distribution characteristics2015

    • Author(s)
      Kyoden, Yasue, Ishida, Akiguchi, Andoh, Takada,Teranishi ,and Hachiga
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 54 Issue: 1 Pages: 1-6

    • DOI

      10.7567/jjap.54.012501

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Power spectrum and blood flow velocity images obtained by dual-beam backscatter laser Doppler velocimetry2014

    • Author(s)
      Ishida, Yasue, Hachiga, Andoh, Akiguchi, Kuraishi, Shimizu
    • Journal Title

      Optical Review

      Volume: 21 Issue: 4 Pages: 461-467

    • DOI

      10.1007/s10043-014-0071-4

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Live blood flow imaging using cross-sectional multipoint LDV2017

    • Author(s)
      N. Shoji, S. Akiguchi, T. Kyoden, T. Andoh, T. Hachiga, N. Yamada, M. Baba
    • Organizer
      International Conference of “Science of Technology Innovation” 2017
    • Place of Presentation
      長岡技術科学大学(新潟県・長岡市)
    • Year and Date
      2017-01-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 近赤外レーザードップラー流速分布計測装置の皮膚癌診断と治療への応用2016

    • Author(s)
      秋口俊輔、荘司成煕、経田僚昭、百生登、保前友高、安東嗣修、八賀正司
    • Organizer
      第55回日本生体生体医工学会予稿集
    • Place of Presentation
      富山国際会議場(富山県・富山市)
    • Year and Date
      2016-04-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] 多点同時LDVによるin-vivo 血流イメージングに影響を及ぼす皮膚の存在とその有効性2016

    • Author(s)
      荘司成煕、秋口俊輔、経田僚昭、百生登、八賀正司、安東嗣修
    • Organizer
      第55回日本生体生体医工学会予稿集
    • Place of Presentation
      富山国際会議場(富山県・富山市)
    • Year and Date
      2016-04-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] Measurement of Relationship between Red Blood Cell Velocity and Movement of Erythrocytes2016

    • Author(s)
      Shunsuke Akiguchi, Tomoaki Kyoden, Tadashi Hachiga
    • Organizer
      International Conference on Engineering and Technology 2016
    • Place of Presentation
      富山県民会館(富山県・富山市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Study on Multipoint Temperature Measurement Using Laser Interferometry2016

    • Author(s)
      N. Shoji, S. Akiguchi, T. Kyoden, T. Homae, N. Momose, H. Yoshioka, T. Hachiga
    • Organizer
      International Conference on Engineering and Technology 2016
    • Place of Presentation
      富山県民会館(富山県・富山市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] レーザー干渉法を利用した多点同時温度センサーの開発に向けた基礎検討2015

    • Author(s)
      百生登,荘司成煕,経田僚昭,義岡秀晃,保前友高,冨田栄二,秋口俊輔,八賀正司
    • Organizer
      日本伝熱学会北陸信越支部秋季セミナー
    • Place of Presentation
      信州大学 (長野県長野市)
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 面計測LDVによる時間変動流速場の計測ー生体計測への応用と今後の展開ー2015

    • Author(s)
      荘司成煕,秋口俊輔,経田僚昭,安東嗣修,百生登,寺西恒宣,八賀正司
    • Organizer
      日本伝熱学会北陸信越支部秋季セミナー
    • Place of Presentation
      信州大学 (長野県長野市)
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report
  • [Presentation] In-situ LDV monitoring system using two-dimensional optical fiber array2015

    • Author(s)
      T.Kyoden, H.Ishida, N.Shoji, T.Andoh, S.Akiguchi, and T.Hachiga
    • Organizer
      The 5th International Symposium on Organic and Inorganic Electronic Materials and Related Nanotechnologies
    • Place of Presentation
      新潟コンベンションセンター (新潟県新潟市)
    • Year and Date
      2015-06-16
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 血管内血流動場をリアルタイムでモニタリングする計測手法と解析ソフトウェアの基盤構築2015

    • Author(s)
      荘司成煕,秋口俊輔,百生登,経田僚昭,八賀正司,安東嗣修,石田弘樹
    • Organizer
      日本伝熱学会北陸信越支部春季セミナー
    • Place of Presentation
      富山大学 (富山県富山市)
    • Year and Date
      2015-05-09
    • Related Report
      2015 Research-status Report
  • [Presentation] 近赤外レーザドップラー流速分布測定装置の生体計測への応用2014

    • Author(s)
      高橋里奈,経田僚昭,石田弘樹,秋口俊輔,安東嗣修,高田洋吾, 寺西恒宣,八賀正司
    • Organizer
      日本機械学会流体工学部門講演会講演論文集
    • Place of Presentation
      富山大学
    • Year and Date
      2014-10-25 – 2014-10-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 狭窄部のある矩形流路内の脈動流を対象とした流動解析2014

    • Author(s)
      安部将太郎, 高田洋吾, 経田僚昭, 石田弘樹, 秋口俊輔, 寺西恒宣, 八賀正司, 安東嗣修
    • Organizer
      日本伝熱学会北陸信越支部 2014年度秋季セミナー
    • Place of Presentation
      長岡技大(新潟県)
    • Year and Date
      2014-10-17 – 2014-10-18
    • Related Report
      2014 Research-status Report
  • [Presentation] マイクロ多点同時計測LDV 法の生体計測への応用(狭窄部のあるマイクロ流路内の脈動流速分布の瞬時計測)2014

    • Author(s)
      谷野恭平, 酒井諒, 経田僚昭, 寺西恒宣, 石田弘樹, 秋口俊輔, 八賀正司, 安東 嗣修, 高田洋吾
    • Organizer
      日本伝熱学会北陸信越支部 2014年度春季セミナー
    • Place of Presentation
      富山高専
    • Year and Date
      2014-05-10
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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