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A Novel Therapy with Bright Light System in Parkinson's Disease

Research Project

Project/Area Number 26350525
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionToneyama National Hospital

Principal Investigator

ENDO TAKUYUKI  独立行政法人国立病院機構刀根山病院(臨床研究部), 独立行政法人国立病院機構刀根山病院, 研究員(移行) (40573225)

Co-Investigator(Kenkyū-buntansha) 佐古田 三郎  独立行政法人国立病院機構 刀根山病院(臨床研究部), 独立行政法人国立病院機構刀根山病院, 病院長 (00178625)
Research Collaborator AKASHI Makoto  山口大学, 時間学研究所, 教授 (30398119)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords生体制御・治療 / 生体制御治療
Outline of Final Research Achievements

We examined effects of bright light therapy (BLT) on non-motor symptoms such as insomnia and nocturia, and on motor symptoms in Parkinson’s disease (PD) patients. Patients with insomnia(17), nocturia(24) and gait disturbance(21) were all exposed to white fluorescent light for 1 hour once daily commencing in 7 pm to 10 pm in most patients. Subjects were assessed on initial presentation prior to receiving BLT and twelve weeks after the commencement of BLT. Total sleep time and number of nocturnal urination were assessed from circadian record instruction sheet filled by subjects themselves. Ten-meter walk tests were conducted by an experienced rehabilitator. In our results, BLT led to a significant improvement in insomnia, nocturia, and ten-meter walk time. Furthemore, we assessed the circadian clock gene expression in PD patients using hair follicle cells and revealed that the phase of some clock gene expression shifted after light therapy.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (8 results)

All 2017 2016 2015 2014 Other

All Journal Article (1 results) (of which Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 1 results) Remarks (2 results)

  • [Journal Article] パーキンソン病に対する高照度光療法2016

    • Author(s)
      遠藤 卓行
    • Journal Title

      BIO Clinica

      Volume: 31 Pages: 971-974

    • Related Report
      2016 Annual Research Report
    • Acknowledgement Compliant
  • [Presentation] The Effect of Bright Light Therapy on Night-time problems and Motor Symptoms in Parkinson's Disease2017

    • Author(s)
      Takuyuki Endo
    • Organizer
      13th International Conference on Alzheimer’s and Parkinson’s Diseases
    • Place of Presentation
      オーストリア、ウイーン
    • Year and Date
      2017-03-31
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] パーキンソン病患者における時計遺伝子発現の概日位相の検討2016

    • Author(s)
      遠藤 卓行
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] パーキンソン病に対する高照度光療法(第二報)-運動症状への効果2015

    • Author(s)
      遠藤卓行、Gregory L. Willis、齋藤朋子、木村紀久、山寺みさき、猪山昭徳、井上貴美子、豊岡圭子、松村剛、藤村晴俊、佐古田三郎
    • Organizer
      第33回日本神経治療学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-11-26 – 2015-11-28
    • Related Report
      2014 Research-status Report
  • [Presentation] パーキンソン病に対する高照度光療法(第二報)―運動症状への効果2015

    • Author(s)
      遠藤 卓行
    • Organizer
      第33回日本神経治療学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-11-26
    • Related Report
      2015 Research-status Report
  • [Presentation] パーキンソン病に対する高照度光療法(第一報)-Night-time problemsへの効果2014

    • Author(s)
      遠藤卓行、Gregory L. Willis、猪山昭徳、豊岡圭子、松村剛、藤村晴俊、佐古田三郎
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      博多
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Research-status Report
  • [Remarks] 光療法市民公開講座 概要と質疑応答

    • URL

      http://www.toneyama-hosp.jp/patient/workshop/koen_koukaikouza_20141002.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] パーキンソン病の高照度光療法(光療法市民公開講座 概要と質疑応答)

    • URL

      http://www.toneyama-hosp.jp/patient/workshop/koen_koukaikouza_20141002.html

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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