Development of new intravascular optical coherence tomography for detecting lipid core in coronary atherosclerotic plaques
Project/Area Number |
26350542
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Medical systems
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Research Institution | Wakayama Medical University |
Principal Investigator |
Kubo Takashi 和歌山県立医科大学, 医学部, 准教授 (30316096)
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Co-Investigator(Kenkyū-buntansha) |
赤阪 隆史 和歌山県立医科大学, 医学部, 教授 (70322584)
|
Research Collaborator |
HASEGAWA Takeyoshi
SHIMOKADA Ai
NISHIGUCHI Tsuyoshi
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 光干渉断層法 / 冠動脈疾患 / 動脈硬化 / 脂質 / 赤外線 |
Outline of Final Research Achievements |
Using optical coherence tomography (OCT) and spectroscopic algorism, we developed new intravascular imaging method for tissue characterization of coronary atherosclerotic plaques. In the present study, we showed that this new intravascular OCT allows us to detect lipid-rich necrotic core in coronary atherosclerotic plaques which might be associated with the onset of acute myocardial infarction.
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Report
(5 results)
Research Products
(79 results)
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[Journal Article] Clinical Utility of Combined Optical Coherence Tomography and Near-Infrared Spectroscopy for Assessing the Mechanism of Very Late Stent Thrombosis.2018
Author(s)
Ino Y, Kubo T, Kameyama T, Shimamura K, Terada K, Matsuo Y, Kitabata H, Shiono Y, Kashiwagi M, Kuroi A, Maniwa N, Ota S, Ozaki Y, Tanaka A, Hozumi T, Akasaka T.
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Journal Title
JACC Cardiovasc Imaging
Volume: 12
Pages: 1-5
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Identification of High Risk Plaques for Acute Coronary Syndrome Using Coronary CT Angiography and Computational Fluid Dynamics.2018
Author(s)
Lee MJ, Choi G, Koo BK, Hwang D, Park J, Zhang J, Kim KJ, Tong Y, Kim HJ, Grady L, Taylor C, Doh JH, Shin ES, Cho YS, Choi SU, Chun EJ, Choi JH, Christiansen E, Nieman K, Otake H, Penicka M, Bruyne BD, Kubo T, Akasaka T, Narula J, Douglas P, Kim HS.
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Journal Title
JACC Cardiovasc Imaging
Volume: 9
Pages: 1-5
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Optical frequency domain imaging versus intravascular ultrasound in percutaneous coronary intervention (OPINION trial): results from the OPINION imaging study. JACC Cardiovasc Imaging.2018
Author(s)
Otake H, Kubo T, Takahashi H, Shinke T, Okamura T, Hibi K, Nakazawa G, Morino Y, Shite J, Fusazaki T, Kozuma K, Ioji T, Kaneda H, Akasaka T.
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Journal Title
JACC Cardiovasc Imaging
Volume: 11
Pages: 111-123
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Automated lipid-rich plaque detection with short wavelength infra-red OCT system.2017
Author(s)
Shimokado A, Kubo T, Nishiguchi T, Taruya A, Teraguchi I, Ohta S, Ozaki Y, Kashiwagi M, Shimamura K, Kuroi A, Kameyama T, Shiono Y, Yamano T, Matsuo Y, Kitabata H, Ino Y, Hozumi T, Tanaka A, Akasaka T.
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Journal Title
Eur Heart J Cardiovasc Imaging
Volume: 27
Pages: 1-5
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Clinical Relevance of 18F-Sodium Fluoride Positron-Emission Tomography in Noninvasive Identification of High-Risk Plaque in Patients With Coronary Artery Disease.2017
Author(s)
Lee JM, Bang JI, Koo BK, Hwang D, Park J, Zhang J, Yaliang T, Suh M, Paeng JC, Shiono Y, Kubo T, Akasaka T.
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Journal Title
Circ Cardiovasc Imaging
Volume: 10
Pages: 1-6
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Optical frequency domain imaging versus intravascular ultrasound in percutaneous coronary intervention (OPINION trial): one-year angiographic and clinical results.2017
Author(s)
Kubo T, Shinke T, Okamura T, Hibi K, Nakazawa G, Morino Y, Shite J, Fusazaki T, Otake H, Kozuma K, Ioji T, Kaneda H, Serikawa T, Kataoka T, Okada H, Akasaka T.
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Journal Title
Eur Heart J
Volume: 38
Pages: 3139-3147
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Assessment of Vascular Response after Drug-eluting Stents Implantation in Patients with Diabetes Mellitus: An Optical Coherence Tomography Sub-study of the J-DESsERT2016
Author(s)
Kubo T, Akasaka T, Tanimoto T, Takano M, Seino Y, Nasu K, Itoh T, Mizuno K, Okura H, Shinke T, Kotani J, Ito S, Yokoi H, Muramatsu T, Nakamura M, Nanto S
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Journal Title
Heart Vessels.
Volume: 31
Pages: 465-473
Related Report
Peer Reviewed
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[Journal Article] Optimal threshold of post-intervention minimum stent area to predict in-stent restenosis in small coronary arteries: An optical coherence tomography analysis2016
Author(s)
Matsuo Y, Kubo T, Aoki H, Satogami K, Ino Y, Kitabata H, Taruya A, Nishiguchi T, Teraguchi I, Shimamura K, Shiono Y, Orii M, Yamano T, Tanimoto T, Yamaguchi T, Hirata K, Tanaka A, Akasaka T
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Journal Title
Catheter Cardiovasc Interv
Volume: 87
Pages: E9-E14
Related Report
Peer Reviewed
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[Journal Article] Optical coherence tomography predictors for edge restenosis after everolimus-eluting stent implantation2016
Author(s)
Ino Y, Kubo T, Matsuo Y, Yamaguchi T, Shiono Y, Shimamura K, Katayama Y, Nakamura T, Aoki H, Taruya A, Nishiguchi T, Satogami K, Yamano T, Kameyama T, Orii M, Oota S, Kuroi A, Kitabata H, Tanaka A, Hozumi T, Akasaka T
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Journal Title
Circ Cardiovasc Interv
Volume: 9
Pages: 4231
Related Report
Peer Reviewed / Open Access
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[Journal Article] Superficial calcium fracture after percutaneous coronary intervention as assessed by optical coherence tomography.2015
Author(s)
Kubo T, Shimamura K, Ino Y, Yamaguchi T, Matsuo Y, Shiono Y, Taruya A, Nishiguchi T, Shimokado A, Teraguchi I, Orii M, Yamano T, Tanimoto T, Kitabata H, Hirata K, Tanaka A, Akasaka T.
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Journal Title
JACC Cardiovasc Imaging.
Volume: 8
Pages: 1228-1229
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Comparison of Neointimal Coverage between Everolimus-Eluting Stents and Sirolimus-Eluting Stents: An Optical Coherence Tomography Substudy of the RESET.2015
Author(s)
Kubo T, Akasaka T, Kozuma K, Kimura K, Kawamura M, Sumiyoshi T, Ino Y, Morino Y, Tanabe K, Kadota K, Kimura T
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Journal Title
EuroIntervention
Volume: 11
Pages: 564-571
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Feasibility of optical coronary tomography in quantitative measurement of coronary arteries with lipidic plaque.2015
Author(s)
Kubo T, Yamano T, Liu Y, Ino Y, Shiono Y, Orii M, Taruya A, Nishiguchi T, Shimokado A, Teraguchi I, Tanimoto T, Kitabata H, Yamaguchi T, Hirata K, Tanaka A, Akasaka T.
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Journal Title
Circ J
Volume: 79
Pages: 600-606
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Vascular Responses to Drug-Eluting Stents with Biodegradable Polymer versus Durable Polymer: An Optical Coherence Tomography Sub-study of the NEXT.2014
Author(s)
Kubo T, Akasaka T, Kozuma K, Kimura K, Fusazaki T, Okura H, Shinke T, Ino Y, Hasegawa T, Takashima H, Takamisawa I, Yamaguchi H, Igarashi K, Kadota K, Tanabe K, Nakagawa Y, Muramatsu T, Morino Y, MD, Kimura T
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Journal Title
Circ J.
Volume: 78
Pages: 2408-2414
Related Report
Peer Reviewed / Open Access
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[Journal Article] Effect of Atorvastatin Therapy on the Fibrous Cap Thickness in Coronary Atherosclerotic Plaque as Assessed by Optical Coherence Tomography: The EASY-FIT Study.2014
Author(s)
Komukai K, Kubo T, Kitabata H, Matsuo Y, Ozaki Y, Takarada S, Okumoto Y, Shiono Y, Orii M, Shimamura K, Ueno S, Yamano T, Tanimoto T, Ino Y, Yamaguchi T, Kumiko H, Tanaka A, Imanishi T, Akagi H, Akasaka T.
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Journal Title
J Am Coll Cardiol.
Volume: 64
Pages: 2207-2217
Related Report
Peer Reviewed / Open Access
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[Journal Article] Difference of ruptured plaque morphology between asymptomatic coronary artery disease and non-ST elevation acute coronary syndrome patients: An optical coherence tomography study.2014
Author(s)
Shimamura K, Ino Y, Kubo T, Nishiguchi T, Tanimoto T, Ozaki Y, Satogami K, Orii M, Shiono Y, Komukai K, Yamano T, Matsuo Y, Kitabata H, Yamaguchi T, Hirata K, Tanaka A, Imanishi T, Akasaka T.
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Journal Title
Atherosclerosis.
Volume: 235
Pages: 532-537
Related Report
Peer Reviewed / Open Access
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[Journal Article] Comparison of diagnostic accuracy between multidetector computed tomography and virtual histology intravascular ultrasound for detecting optical coherence tomography-derived fibroatheroma.2014
Author(s)
Kashiwagi M, Tanaka A, Kitabata H, Ozaki Y, Komukai K, Tanimoto T, Ino Y, Kubo T, Hirata K, Imanishi T, Akasaka T.
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Journal Title
Cardiovasc Interv Ther.
Volume: 29
Pages: 102-108
Related Report
Peer Reviewed
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[Journal Article] Impact of glucose fluctuation and monocyte subsets on coronary plaque rupture.2014
Author(s)
Teraguchi I, Imanishi T, Ozaki Y, Tanimoto T, Orii M, Shiono Y, Shimamura K, Ishibashi K, Yamano T, Ino Y, Yamaguchi T, Hirata K, Kubo T, Akasaka T.
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Journal Title
Nutr Metab Cardiovasc Dis.
Volume: 24
Pages: 309-314
Related Report
Peer Reviewed
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[Journal Article] Association between P-selectin glycoprotein ligand-1 and pathogenesis in acute coronary syndrome assessed by optical coherence tomography.2014
Author(s)
Ozaki Y, Imanishi T, Teraguchi I, Nishiguchi T, Orii M, Shiono Y, Shimamura K, Ishibashi K, Tanimoto T, Yamano T, Ino Y, Yamaguchi T, Kubo T, Akasaka T.
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Journal Title
Atherosclerosis.
Volume: 233
Pages: 697-703
Related Report
Peer Reviewed / Open Access
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[Journal Article] Comparison of Longitudinal Geometric Measurement in Human Coronary Arteries between Frequency-domain Optical Coherence Tomography and Intravascular Ultrasound.2014
Author(s)
Liu Y, Shimamura K, Kubo T, Tanaka A, Kitabata H, Ino Y, Tanimoto T, Shiono Y, Orii M, Yamano T, Yamaguchi T, Hirata K, Imanishi T, Akasaka T.
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Journal Title
Int J Cardiovasc Imaging.
Volume: 30
Pages: 271-277
Related Report
Peer Reviewed / Open Access
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[Presentation] OCT Follow-Up Substudy from a Randomized Trial of OFDI-Guided PCI vs. IVUS-Guided PCI2016
Author(s)
Oatke M, Kubo T, Takahashi H, Shinke T, Okamura T, Hibi K, Nakazawa G, Morino Y, Shite J, Fusazaki T, Kozuma K, Akasaka T
Organizer
TCT
Place of Presentation
Washington DC, USA
Year and Date
2016-10-30 – 2016-11-02
Related Report
Int'l Joint Research
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[Presentation] Clinical impact of coronary calcium fracture by percutaneous coronary intervention on the outcomes after everolimus-eluting stent implantation: An optical coherence tomography study.2015
Author(s)
Kubo T, Shimamura K, Katayama Y, Ino Y, Yamaguchi T, Matsuo Y, Shiono Y, Taruya A, Nishiguchi T, Orii M, Yamano T, Hirata K, Tanaka A, Akasaka T.
Organizer
EuroPCR 2015
Place of Presentation
Paris, France
Year and Date
2015-05-19 – 2015-05-22
Related Report
Int'l Joint Research
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