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The adverse effect of ultrasonic exposure with acoustic radiation force (ARF) impulse on the rabbit heart

Research Project

Project/Area Number 26350544
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical systems
Research InstitutionJichi Medical University

Principal Investigator

Taniguchi Nobuyuki  自治医科大学, 医学部, 教授 (10245053)

Co-Investigator(Kenkyū-buntansha) 小形 幸代  自治医科大学, 医学部, 講師 (10448847)
石黒 保直  自治医科大学, 医学部, 非常勤講師 (10646326)
笹沼 英紀  自治医科大学, 医学部, 准教授 (90511709)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords音響放射力インパルス / 心臓 / 造影超音波検査 / 不整脈 / 肺 / 傷害 / 心電図
Outline of Final Research Achievements

ARFI is a modality for elasticity imaging of various organs using shear waves. In some situations, the heart is a candidate for elasticity evaluation with ARFI. Additionally, an ultrasound contrast agent provides information of the cardiac muscle. This study aimed to evaluate ARFI’s effect on the heart concomitantly with contrast agents administration. Ultrasound with ARFI was applied to the hearts of rabbits using a single element focused transducer with or without contrast agents administration. They were exposed to ultrasound with a mechanical index of 1.8 or lower. Contrast agent was administered by a bolus injection or drip infusion. Electrocardiograms were recorded to identify arrhythmias during ultrasound exposure. Extrasystolic waves were observed following ultrasound exposure by contrast agents administration. Life threatening arrhythmia was not observed.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report

Research Products

(9 results)

All 2017 2016 2015 2014

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (6 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] The effect of ultrasound with acoustic radiation force on rabbit lung tissue: a preliminary study2016

    • Author(s)
      Noriya Takayama,Yasunao Ishiguro,Nobuyuki Taniguchi, Kazuki Akai,Hideki Sasanuma, Yoshikazu Yasuda,Naotaka Nitta,Iwaki Akiyama
    • Journal Title

      Journal of Medical Ultrasonics.

      Volume: 43 Pages: 481-485

    • DOI

      10.1007/s10396-016-0730-0

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Ultrasound exposure (mechanical index 1.8) with acoustic radiation force impulse evokes extrasystolic waves in rabbit heart under concomitant administration of an ultrasound contrast agent2016

    • Author(s)
      Yasunao Ishiguro, Naotaka Nitta, Nobuyuki Taniguchi, Kazuki Akai, Noriya Takayama, Hideki Sasanuma, Yukiyo Ogata, Yoshikazu Yasuda, Iwaki Akiyama
    • Journal Title

      Journal of Medical Ultrasonics

      Volume: 43 Pages: 3-7

    • DOI

      10.1007/s10396-015-0654-0

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The arrhythmogenetic effect of ultrasonic exposure with acoustic radiation force (ARF) impulse on the rabbit heart with ultrasound contrast agent; perfluorobutane2015

    • Author(s)
      Yasunao Ishiguro, Hideki Sasanuma, Naotaka Nitta, Nobuyuki Taniguchi, Yukiyo Ogata, Yoshikazu Yasuda, Iwaki Akiyama
    • Journal Title

      Journal of Medical Ultrasonics

      Volume: 42 Pages: 47-50

    • DOI

      10.1007/s10396-014-0573-5

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] The Safety of Ultrasound with Acoustic Radiation Force Impulse2017

    • Author(s)
      Hideki Sasanuma and Nobuyuki Taniguchi
    • Organizer
      2017 China-Japan Medical Ultrasonics Symposium
    • Related Report
      2017 Annual Research Report
  • [Presentation] The Effect of Ultrasound with Acoustic Radiation Force Impulse on the Lung: A Preliminary Study in Rabbits2017

    • Author(s)
      Hideki Sasanuma, Noriya Takayama, Kazuma Rifua, Wakana Takanoc, Yasunao Ishiguro, Nobuyuki Taniguchi
    • Organizer
      International Congress on Ultrasonics
    • Related Report
      2017 Annual Research Report
  • [Presentation] The effect of ultrasound with acoustic radiation force impulse on the rabbit lung tissue2016

    • Author(s)
      Noriya Takayama, Hideki Sasanuma, Nobuyuki Taniguchi,
    • Organizer
      BMUS(British Medical Ultrasound Society)
    • Place of Presentation
      York, Racecourse, UK
    • Year and Date
      2016-12-06
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] The extra systolic waves evoked by the ultrasound exposure (mechanical index: 1.8) with acoustic radiation force impulse for the rabbit heart under administration of ultrasound contrast agent2015

    • Author(s)
      Yasunao Ishiguro, Naotaka Nitta, Nobuyuki Taniguchi, Kazuki Akai, Noriya Takayama, Hideki Sasanuma, Yukiyo Ogata, Yoshikazu Yasuda, Iwaki Akiyama
    • Organizer
      Euroson2015
    • Place of Presentation
      Athens, Greece
    • Year and Date
      2015-11-06
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 超音波造影剤投与下の音響放射力インパルス(ARFI : Acoustic Radiation Force Impulse)のウサギ心臓への照射とその期外収縮発現2015

    • Author(s)
      石黒保直, 新田尚隆, 赤井一輝, 高山法也, 小形幸代, 笹沼英紀, 安田是和,谷口信行, 秋山 いわき
    • Organizer
      日本超音波医学会第88回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-23
    • Related Report
      2015 Research-status Report
  • [Presentation] The effect of ultrasound with acoustic radiation force impulse (ARFI)2014

    • Author(s)
      Yasunao Ishiguro, Hideki Sasanuma, Naotaka Nitta, Nobuyuki Taniguchi, Yukiyo Ogata, Yoshikazu Yasuda, Iwaki Akiyama
    • Organizer
      Asian Federation of Societies for Ultrasound in Medicine and Biology
    • Place of Presentation
      Kuala Lumpur, Malaysia
    • Year and Date
      2014-10-30 – 2014-10-31
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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