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A novel therapeutic approach for dysphagia affecting with CNS connectome

Research Project

Project/Area Number 26350578
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Yamawaki Masanaga  京都府立医科大学, 医学(系)研究科(研究院), 教授 (30302855)

Co-Investigator(Kenkyū-buntansha) 檀 一平太  中央大学, 理工学部, 教授 (20399380)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords嚥下障害 / 脳機能画像 / リハビリテーション / コネクトーム / 嚥下運動 / 抑制シグナル / 脳機能マッピング / brain mapping / dysphagia / connectome / deglutition
Outline of Final Research Achievements

The swallowing performance is influenced by various conditions. There are subcortical and cortical centers above the brainstem that induced swallowing movement, however, their specific role and connections are not well understood from the viewpoint of postural change. We applied functional near-infrared spectroscopy (fNIRS), an optical method that non-invasively measure cortical hemodynamics, for brain mapping in swallowing with postural change.The haemodynamic pattern during swallowing appeared different in sitting versus in supine position in BA 6 and BA 40. Our findings suggest that the sensory input is more important in deglutition. We targeted therapeutic points by mapping functional connectivity on swallowing movements.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (11 results)

All 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (5 results) (of which Int'l Joint Research: 2 results,  Invited: 4 results)

  • [Int'l Joint Research] マンチェスター大学(英国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 高齢者の摂食嚥下障害とその食支援2016

    • Author(s)
      山脇正永
    • Journal Title

      老年医学

      Volume: 54 Pages: 7-10

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 認知症と嚥下障害2015

    • Author(s)
      山脇正永
    • Journal Title

      嚥下医学

      Volume: 5 Pages: 5-10

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 嚥下障害の神経メカニズム2015

    • Author(s)
      山脇正永
    • Journal Title

      日本早期認知症学会誌

      Volume: 8 Pages: 26-30

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 新たな嚥下障害治療法・対応法の開発2015

    • Author(s)
      山脇正永
    • Journal Title

      地域ケアリング

      Volume: 17 Pages: 68-71

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Estrogenic regulation of histamine receptor subtype H1 expression in ventromedial nucleus of the hypothalamus in female rats.2014

    • Author(s)
      Mori H., Matsuda K. I., Yamawaki M., Kawata M.
    • Journal Title

      PLoS One

      Volume: 印刷中 Issue: 5 Pages: 96232-96232

    • DOI

      10.1371/journal.pone.0096232

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 多職種医療プロフェッショナル教育2016

    • Author(s)
      山脇正永
    • Organizer
      日本病院薬剤師会 近畿学術大会
    • Place of Presentation
      京都
    • Year and Date
      2016-01-24
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Cortical Mechanisms for the Integration of Posture and Swallowing Movement: A fNIRS Study.2016

    • Author(s)
      Yamawaki M, Matsuda G, Shibano S, Dan I
    • Organizer
      European Society for Swallowing Disorders
    • Place of Presentation
      Milano (Italy)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Functional Connectivity on Swallowing Movement: A fNIRS Study.2016

    • Author(s)
      Yamawaki M, Matsuda G, Shibano S, Dan I
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego (USA)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 神経難病の摂食・嚥下障害2015

    • Author(s)
      山脇正永
    • Organizer
      日本摂食嚥下リハビリテーション学会
    • Place of Presentation
      京都
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 摂食・嚥下運動の病態生理:脳機能からみたメカニズム2014

    • Author(s)
      山脇正永
    • Organizer
      日本摂食嚥下リハビリテーション学会
    • Place of Presentation
      東京
    • Year and Date
      2014-09-05 – 2014-09-07
    • Related Report
      2014 Research-status Report
    • Invited

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Published: 2014-04-04   Modified: 2018-03-22  

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