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Deep rTMS on medial cortex for acute stroke patients

Research Project

Project/Area Number 26350589
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionInternational University of Health and Welfare

Principal Investigator

Sasaki Nobuyuki  国際医療福祉大学, 大学病院, 教授 (60328325)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords経頭蓋磁気刺激 / 脳卒中 / リハビリテーション / 下肢麻痺 / 自発性 / 高次脳機能障害 / 片麻痺 / アパシー / 急性期 / 非侵襲的脳刺激
Outline of Final Research Achievements

No study has examined the usefulness of repetitive transcranial magnetic stimulation (rTMS) for lower limb hemiparesis and post stroke apathy in patients with acute stroke. 21 acute stroke patients were randomly assigned into two groups: the high frequency (HF)-rTMS group and the sham stimulation group. Patients received rTMS for 5 consecutive days. The improvement in paretic leg motor function was significant in the HF-rTMS group.
13 chronic stroke patients were assigned randomly to two groups: rTMS group and sham stimulation group. The patients received 5 sessions of either HF-rTMS over the region spanning from the dorsal anterior cingulate cortex (dACC) to medial prefrontal cortex (mPFC) or sham stimulation for 5 days. The severity of apathy was significantly improved in the rTMS group. This rTMS application was also safe and feasible for recovery of apathy in acute phase.
Application of rTMS has potential to be a new rehabilitation therapy for patients in the acute phase of stroke.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report

Research Products

(15 results)

All 2017 2016 2015 2014

All Journal Article (6 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 2 results) Presentation (7 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Book (2 results)

  • [Journal Article] The efficacy of high-frequency repetitive transcranial magnetic stimulation for improving apathy in chronic stroke patients2017

    • Author(s)
      Sasaki N, Hara T, Yamada N, Niimi M, Kakuda W, Abo M
    • Journal Title

      Eur Neurol.

      Volume: 印刷中 Pages: 28-32

    • DOI

      10.1159/000477440

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] High-frequency rTMS on leg motor area in the early phase of stroke.2017

    • Author(s)
      Sasaki N, Abo M, Hara T, Yamada N, Niimi M, Kakuda W
    • Journal Title

      Acta Neurol Belg

      Volume: 117 Pages: 189-194

    • DOI

      10.1007/s13760-016-0687-1

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 脳卒中麻痺治療の最前線~急性期脳卒中上肢麻痺・下肢麻痺に対する反復性経頭蓋磁気刺激(rTMS)2015

    • Author(s)
      佐々木信幸
    • Journal Title

      医工学治療

      Volume: 27 Pages: 108-112

    • Related Report
      2015 Research-status Report
  • [Journal Article] 急性期症例へのTMS.2015

    • Author(s)
      佐々木信幸
    • Journal Title

      Modern Physician

      Volume: 35 Pages: 1501-1505

    • Related Report
      2015 Research-status Report
  • [Journal Article] Bilateral high- and low-frequency rTMS in acute stroke patients with hemiparesis: A comparative study with unilateral high-frequency rTMS.2014

    • Author(s)
      Nobuyuki Sasaki
    • Journal Title

      Brain Injury

      Volume: 28 Pages: 1682-1686

    • DOI

      10.3109/02699052.2014.947626

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Repetitive Transcranial Magnetic Stimulation for Hemiparesis before Pacemaker Implantation in a Case with Cerebral Embolism due to a Left Atrial Myxoma2014

    • Author(s)
      佐々木信幸
    • Journal Title

      Jpn J Rehabil Med

      Volume: 51 Issue: 6 Pages: 378-382

    • DOI

      10.2490/jjrmc.51.378

    • NAID

      130004678794

    • ISSN
      1881-3526, 1881-8560
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 回復期脳卒中患者の内側前頭前皮質及び背側帯状回への高頻度rTMS(ケースシリーズ)2016

    • Author(s)
      佐々木信幸,安保雅博
    • Organizer
      第53回日本リハビリテーション医学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2016-06-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] 慢性期脳卒中患者の内側前頭前皮質及び背側前帯状回への高頻度rTMS2016

    • Author(s)
      佐々木信幸,安保雅博
    • Organizer
      第41回日本脳卒中学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2016-04-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] High-frequency rTMS on leg motor area for acute stroke patients.2015

    • Author(s)
      Nobuyuki Sasaki
    • Organizer
      The 1st Asia-Oceanian Congress for NeuroRehabilitation
    • Place of Presentation
      Seoul
    • Year and Date
      2015-09-04
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Clinical Practice of Therapeutic rTMS for Post-Stroke Patients~Our proposed protocol and its clinical results.2015

    • Author(s)
      Nobuyuki Sasaki
    • Organizer
      The 1st Asia-Oceanian Congress for NeuroRehabilitation
    • Place of Presentation
      Seoul
    • Year and Date
      2015-09-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 急性期重症者にこそ重要なリハビリテーション介入2015

    • Author(s)
      佐々木信幸
    • Organizer
      第19回エンドトキシン血症救命治療研究会
    • Place of Presentation
      江陽グランドホテル
    • Year and Date
      2015-01-23
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 回復期リハビリテーションに必要な評価2014

    • Author(s)
      佐々木信幸
    • Organizer
      第2回医師のための総合リハビリテーション講座
    • Place of Presentation
      ベルサール九段
    • Year and Date
      2014-08-30
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 発症早期の脳卒中患者の下肢麻痺に対する高頻度rTMSの効果.2014

    • Author(s)
      佐々木信幸
    • Organizer
      第51回日本リハビリテーション医学会学術集会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2014-06-06
    • Related Report
      2014 Research-status Report
  • [Book] 治療を支える疾患別リハビリテーション栄養.2016

    • Author(s)
      佐々木信幸
    • Total Pages
      313
    • Publisher
      南江堂
    • Related Report
      2015 Research-status Report
  • [Book] 最新リハビリテーション医学2016

    • Author(s)
      佐々木信幸
    • Total Pages
      456
    • Publisher
      医歯薬出版
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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