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The fundamental structure for the development of the prevention program of the chronic pain of locomotor organs

Research Project

Project/Area Number 26350640
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionAichi Medical University

Principal Investigator

Mika Ohmichi  愛知医科大学, 医学部, 助教 (30581079)

Co-Investigator(Kenkyū-buntansha) 大道 裕介  愛知医科大学, 医学部, 講師 (50506673)
内藤 宗和  愛知医科大学, 医学部, 教授 (10384984)
安井 正佐也  愛知医科大学, 医学部, 助教 (10723695)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords運動習慣 / 予防 / 慢性痛 / 不動化 / 精神行動 / 慢性疼痛 / 自発運動 / 情動行動 / 運動 / 情動 / 扁桃体
Outline of Final Research Achievements

The aim of the present study is to evaluate whether the exercise habit is effective against the chronic pain. In order to do this, we let the rats exercise freely before treatment of post-cast chronic pain model (CPCP) and then we evaluated the effect of the exercise on pain behavior. Because it was suggested that two factors greatly influence voluntary exercise: the frequency of human intervention in the exercise environment and the negative mental state (anxiety, fear and so on) before CPCP treatment, it is necessary to evaluate mental behavior before the CPCP treatment. For the correct assessment of pain behavior, restrictions were placed on the frequency of interventions. In the environment where human intervention frequency was restricted, the mechanical hyperalgesia and lumbar astrocyte activation were attenuated. The analgesic effects correlated with the amount of exercise. It was suggested that establishment of exercise habits could lead to the prevention of chronic pain.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report

Research Products

(5 results)

All 2017 2016 2014

All Presentation

  • [Presentation] ラット後肢不動によって生じた酸化ストレスに起因する広範囲機械痛覚増強2017

    • Author(s)
      大道裕介
    • Organizer
      第122回日本解剖学会総会・全国学術集会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] ラット後肢不動後に生じる広範囲機械痛覚増強の病態解明:酸化ストレスにより生じた神経原性炎症の関与2016

    • Author(s)
      大道裕介
    • Organizer
      第76回日本解剖学会中部支部学術集会
    • Place of Presentation
      長野
    • Year and Date
      2016-10-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 不動化が誘発する自発痛関連行動と広範囲機械痛覚過敏における扁桃体ドパミンの動態2016

    • Author(s)
      大道裕介
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      福島
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 不動化と痛み2016

    • Author(s)
      大道裕介
    • Organizer
      第3回筋性疼痛研究会(招待講演)
    • Place of Presentation
      愛知
    • Year and Date
      2016-01-09
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] ギプス固定後慢性痛モデルラットの広範囲機械痛覚過敏は明らかな神経損傷に起因しない2014

    • Author(s)
      大道 裕介,大道 美香,牛田 享宏,佐藤 純,中野 隆
    • Organizer
      第74回中部支部学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2014-10-21 – 2014-10-22
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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