| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Using senescent mice (24-month-old), I investigated the adaptive changes in endoplasmic reticulum stress-linked molecules in skeletal muscle. Although we observed the marked increase in the amount of IRE-1a and PKCtheta protein in cytosol of aged muscle fibers, these expressing position are not equal at those position of autophagy-linked molecules. Long-term low-protein-diet did not attenuate sarcopenic symptom. Supplementation with resveratrol, which decrease endoplasmic reticulum stress, attenuated muscle atrophy after denervation in mice.
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