What is the mechanism underlying habitual physical exercise-induced browning of skeletal muscle in interscapular region?

• Project/Area Number: 26350819
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: Asahikawa Medical College (2016); Kyorin University (2014-2015)
• Principal Investigator: Ogasawara Junetsu 旭川医科大学, 医学部, 講師 (20415110)
• Co-Investigator(Renkei-kenkyūsha): SAKURAI Takuya 杏林大学, 医学部, 講師 (20353477) ; KIZAKI Takako 杏林大学, 医学部, 教授 (00322446) ; OHNO Hideki 杏林大学, 医学部, 名誉教授 (00133819)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 褐色脂肪細胞 / 肩甲部骨格筋 / 分化誘導 / 身体運動 / ＰＲＤＭ16 / ＥＨＭＴ1 / 褐色脂肪細胞化 / PRDM16 / TLE3 / 走運動トレーニング / 骨格筋前駆細胞 / myf-5陽性骨格筋前駆細胞 / mfsd2a / 液性因子 / UCP-1 / 急性水泳運動

Outline of Final Research Achievements

It has demonstrated that the precursor of skeletal muscle cells, MYF-5-positive precursors, differentiate into brown adipocyte via transcriptional regulation of PRDM16 in interscapular. Brown adipocyte burns substrates, including fatty acid and glucose, to produce heat which is accompanied by rising energy consumption. Thus, it has been expected to provide a novel therapeutic intervention against obesity and obesity-related disease through the capacity of brown adipocytes. In the present study, in interscapular, it was shown that acute swimming exercise activated molecules of browning, although no changes were observed by acute running exercise. On the other hand, habitual running exercise attenuated significantly the mass of brown adipose tissue with increasing the differentiation into skeletal muscle in this region. These results suggest that both environmental factor and exercise pattern play a key role in exercise-induced browning of MYF-5-positive precursor cells in interscapular.

Research Products

• [Journal Article] Regular Voluntary Exercise Potentiates Interleukin-1ß and Interleukin-18 Secretion by Increasing Caspase-1 Expression in Murine Macrophages (2017)
  • Author(s): Shirato K, Imaizumi K, Sakurai T, Ogasawara J, Ohno H, Kizaki T.
  • Journal Title: Mediators Inflamm. Volume: 2017 Pages: 9290416-9290416
  • DOI: 10.1155/4792
  • Peer Reviewed / Open Access
• [Journal Article] xercise training attenuates the dysregulated expression of adipokines and oxidative stress in white adipose tissue . (2017)
  • Author(s): Sakurai T, Ogasawara J, Shirato K, Izawa T, Oh-ishi S, Ishibashi Y, Radak Z, Ohno H, and Kizaki T.
  • Journal Title: Oxid. Med. Cell Longev. Volume: 2017 Pages: 9410954-9410954
  • DOI: 10.4161/oxim.2.5.9441
  • Peer Reviewed / Open Access
• [Journal Article] Improvement effects of regular exercise on inflammatory responses to bacterial pathogens in resident and recruited macrophages. (2017)
  • Author(s): Shirato K, Sato S, Imaizumi K, Sakurai T, Ogasawara J, Ohno H, Kizaki T.
  • Journal Title: Macrophage (Host) Volume: 4
  • Peer Reviewed
• [Journal Article] Enzyme-Treated Asparagus Extract Prevents Hydrogen Peroxide-Induced Pro-Inflammatory Responses by Suppressing p65 Nuclear Translocation in Skin L929 Fibroblasts (2016)
  • Author(s): Shirato K, Takanari J, Sakurai T, Ogasawara J, Imaizumi K, Ohno H, Kizaki T.
  • Journal Title: Nat. Prod. Commun. Volume: 11 Pages: 1883-1888
  • Peer Reviewed
• [Journal Article] Cerebral artery blood flow and oxygenation in the frontal lobe region in response to a judo chokehold (shimewaza). (2016)
  • Author(s): Haga S, Sakurai T, Hamaoka T, Esaki K, Ueya K, Toshinai K, Miyazaki H, Ogasawara J, Shirato K, Hashimoto N, Katsumura T, Nioka S, Chance B, Yamaguchi I, Kizaki T, Ohno H.
  • Journal Title: J. Exerc. Sports Orthop. Volume: 3 Pages: 1-8
  • DOI: 10.15226/2374-6904
  • Peer Reviewed / Open Access
• [Journal Article] Enzyme-Treated Asparagus Extract Attenuates Hydrogen Peroxide-Induced Matrix Metalloproteinase-9 Expression in Murine Skin Fibroblast L929 Cells (2016)
  • Author(s): Shirato K, Takanari J, Ogasawara J, Sakurai T, Imaizumi K, Ohno H, Kizaki T
  • Journal Title: Naural Product Communications Volume: 11
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Cerebral artery blood flow and oxygenation in the frontal lobe region in response to a judo chokehold (shimewaza) (2016)
  • Author(s): Haga S, Sakurai T, Hamaoka T, Esaki K, Ueya K, Toshinai K, Miyazaki H, Ogasawara J, Shirato K, Hashimoto N, Kastumura T, Nioka S, Chance B, Yamaguchi I, Kizaki T, Ohno H
  • Journal Title: Journal of Exercise, Sports & Orthopedics Volume: 3
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Clinical effect of real time pulse rate monitorin with a portable pulsimeter on physical exercise therapy for male patients with type 2 diabetes (2016)
  • Author(s): Sumitani Y, Hosaka T, Susaki Y, FujisawaY, Kuriyama K, TsukadaY, Yokoyama T, Ogasawara J, Nishida S, Inukai K, Okajima Y, Ohno H, Ishida H
  • Journal Title: Diabetology International Volume: 7
  • DOI: 10.1007/s13340-015-0238-7
  • Peer Reviewed / Open Access
• [Journal Article] Habitual exercise training acts as a physiological stimulator for constant activation of lipolytic enzymes in rat primary white adipocytes (2015)
  • Author(s): Ogasawara J, Izawa T, Sakurai T, Shirato K, Ishibashi Y, Ohira Y, Ishida H, Ohno H, Kizaki T
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 465 Pages: 348-353
  • DOI: 10.1016/j.bbrc.2015.06.157
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The Molecular Mechanism Underlying Continuous Exercise Training-Induced Adaptive Changes of Lipolysis in White Adipose Cells. (2015)
  • Author(s): Ogasawara J, Izawa T, Sakurai T, Sakurai T, Shirato K, Ishibashi Y, Ishida H, Ohno H, Kizaki T
  • Journal Title: Journal of Obesity Volume: 2015 Pages: 1-10
  • DOI: 10.1155/2015/473430
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effect of Circadian Rhythm on Clinical and Pathophysiological Conditions and Inflammation. (2015)
  • Author(s): Kizaki T, Sato S, Shirato K, Sakurai T, Ogasawara J, Izawa T, Ohira Y, Suzuki K, Ohno H
  • Journal Title: Crit. Rev. Immunol. Volume: 35 Pages: 261-275
  • DOI: 10.1615/critrevimmunol.2015014925
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Melatonin promotes adipogenesis and mitochondrial biogenesis in 3T3-L1 preadipocytes (2015)
  • Author(s): Kato H, Tanaka G, Masuda S, Ogasawara J, Sakurai T, Kizaki T, Ohno H, Izawa T
  • Journal Title: Journal of Pineal Research Volume: 59 Pages: 267-275
  • DOI: 10.1111/jpi.12259
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] ETAS, an enzyme-treated asparagus extract, attenuates amyloid beta-induced cellular disorder in PC12 cells (2014)
  • Author(s): Ogasawara J, Ito T, Wakame K, Kitadate K, Sakurai T, Sato S, Ishibashi Y, Izawa T, Takahashi K, Ishida H, Takabatake I, Kizaki T, Ohno H
  • Journal Title: Natural Product Communications Volume: 9 Pages: 561-564
  • Peer Reviewed
• [Journal Article] Enzyme-treated asparagus officinalis extract shows neuroprotective effects and attenuates cognitive impairment in senescence-accelerated mice (2014)
  • Author(s): Sakurai T, Ito T, Wakame K, Kitadate K, Arai T, Ogasawara J, Kizaki T, Sato S, Ishibashi Y, Fujiwara T, Akagawa K, Ishida H, and Ohno H
  • Journal Title: Natural Product Communications Volume: 9 Pages: 101-106
  • Peer Reviewed / Open Access
• [Journal Article] Direct and indirect suppression of interleukin-6 gene expression in murine macrophages by nuclear orphan receptor REV-ERBα. (2014)
  • Author(s): Sato S, Sakurai T, Ogasawara J, Shirato K, Ishibashi Y, Oh-ishi S, Imaizumi K, Haga S, Hitomi Y, Izawa T, Ohira Y, Ohno H & Kizaki T
  • Journal Title: The Scientific World Journal Volume: 2014 Pages: 685854-685854
  • DOI: 10.1155/2014/685854
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A circadian clock gene, Rev-erbα, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression (2014)
  • Author(s): Sato S, Sakurai T, Ogasawara J, Takahashi M, Izawa T, Imaizumi K, Taniguchi N, Ohno H, Kizaki T.
  • Journal Title: Journal of Immunology Volume: 192 Pages: 407-417
  • DOI: 10.4049/jimmunol.1590009
  • Peer Reviewed
• [Presentation] 酵素処理アスパラガス抽出物はH2O2による皮膚線維芽細胞株L929のp65核内移行を抑制することにより炎症性応答を軽減する (2016)
  • Author(s): 白土 健, 高成 準, 櫻井拓也, 小笠原準悦, 今泉和彦, 大野秀樹, 木崎節子
  • Organizer: 第89回日本生化学会大会
  • Place of Presentation: 仙台
  • Year and Date: 2016-09-25
• [Presentation] マウスマクロファージのインフラマソーム依存性サイトカイン分泌は自発性走運動により増強される (2016)
  • Author(s): 白土 健, 櫻井拓也, 小笠原準悦, 大野秀樹, 木崎節子
  • Organizer: 第71回日本体力医学会
  • Place of Presentation: 盛岡
  • Year and Date: 2016-09-23
• [Presentation] Neuroprotective effect of ETAS on cellular disorder in HT22 hippocampal cells (2016)
  • Author(s): Ogasawara J, Takanari J, Shirato K, Sakurai T, Ishibashi Y, Ohno H, Kizaki T
  • Organizer: The 24th International Congress on Nutrition and Integrative Medicine
  • Place of Presentation: 札幌
  • Year and Date: 2016-07-23
  • Int'l Joint Research
• [Presentation] PC12 細胞の神経突起形成に及ぼすETAS (enzyme-treated asparagus extract) の効果 (2016)
  • Author(s): 小笠原準悦, 櫻井拓也, 白土 健, 石橋義永, 大野秀樹, 木崎節子.
  • Organizer: 第86回日本衛生学会学術総会
  • Place of Presentation: 旭川
  • Year and Date: 2016-05-11
• [Presentation] 酸化ストレスによる皮膚線維芽細胞のMMP発現誘導に対するETASの効果 (2016)
  • Author(s): 白土 健, 高成 準, 小笠原準悦, 櫻井拓也, 石橋義永, 今泉和彦, 大野秀樹, 木崎節子
  • Organizer: 第86回日本衛生学会学術総会
  • Place of Presentation: 旭川
  • Year and Date: 2016-05-11
• [Presentation] Acute swimming exercise can acceletate the browning of skeletal muscle in interscapular region (2016)
  • Author(s): Ogasawara J, Sakurai T, Shirato K, Ishibashi Y, , Ohno H, Kizaki T
  • Organizer: 第93回日本生理学会大会
  • Place of Presentation: 札幌
  • Year and Date: 2016-03-22
• [Presentation] 運動は肥満に有効か？脂肪細胞の機能変化に着目して (2016)
  • Author(s): 小笠原準悦
  • Organizer: 第168回日本体力医学会関東地方会
  • Place of Presentation: 東京
  • Invited
• [Presentation] マクロファージのO-結合型N-アセチルグルコサミン修飾調節機構に及ぼす運動トレーニングの影響 (2015)
  • Author(s): 白土 健、櫻井拓也、小笠原準悦、今泉和彦、谷口直之、大野秀樹、木崎節子
  • Organizer: 第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] 加齢性慢性炎症性疾患に対する運動効果：マクロファージ時計遺伝子をプローブとして (2015)
  • Author(s): 白土 健、櫻井拓也、小笠原準悦、楊 國昌、大野秀樹、木﨑節子
  • Organizer: 第44回杏林医学会総会
  • Place of Presentation: 三鷹
  • Year and Date: 2015-11-21
• [Presentation] マウス腹腔マクロファージのO-結合型N-アセチルグルコサミン修飾に及ぼす自発性走運動の影響 (2015)
  • Author(s): 白土 健、櫻井拓也、小笠原準悦、石橋義永、今泉和彦、大野秀樹、木崎節子
  • Organizer: 第70回日本体力医学会大会
  • Place of Presentation: 和歌山
  • Year and Date: 2015-09-18
• [Presentation] 時計遺伝子の発現リズムに基づいた運動トレーニングが脂肪分解反応に及ぼす影響 (2015)
  • Author(s): 加藤久詞、田中剛貴、増田慎也、高倉久志、小笠原準悦、櫻井拓也、木崎節子、大野秀樹、井澤鉄也
  • Organizer: 第70回日本体力医学会大会
  • Place of Presentation: 和歌山
  • Year and Date: 2015-09-18
• [Presentation] The TGF-β-TIMP1 pathway, which inhibits glucose uptake in adipocytes, is attenuated by exercise training (2015)
  • Author(s): Sakurai T, Ogasawara J, Shirato K, Ishibashi Y, Ozawa T, Ohira Y, Imaizumi K, Ohno H, Kizaki T
  • Organizer: The 16th International Biochemistry of Exercise Conference (IBEC 2015)
  • Place of Presentation: Sao Paulo, Brazil
  • Year and Date: 2015-09-07
  • Int'l Joint Research
• [Presentation] Effect of acute swimming exercise on switching action of PRDM16 in skeletal muscles (2015)
  • Author(s): Ogasawara J, Izawa T, Sakurai T, Shirato K, Kato H, Ishibashi Y, Ohira Y, Ohno H, Kizaki T
  • Organizer: The 16th International Biochemistry of Exercise Conference (IBEC 2015)
  • Place of Presentation: Sao Paulo, Brazil
  • Year and Date: 2015-09-07
  • Int'l Joint Research
• [Presentation] Voluntary exercise reduces O-linked N-acetylglucosamine levels in murine macrophages (2015)
  • Author(s): Shirato K, Sakurai Y, Ogasawara J, Ishibashi Y, Kato H, Izawa T, Ohira Y, Imaizumi K, Ohno H, Kizaki T
  • Organizer: The 16th International Biochemistry of Exercise Conference (IBEC 2015)
  • Place of Presentation: Sao Paulo, Brazil
  • Year and Date: 2015-09-07
  • Int'l Joint Research
• [Presentation] ETASはPC12細胞の神経突起の形成を促進する (2015)
  • Author(s): 小笠原準悦、高成 準、白土 健、櫻井拓也、大野秀樹、木崎節子
  • Organizer: 第25回体力・栄養・免疫学会大会
  • Place of Presentation: 東京
  • Year and Date: 2015-08-22
• [Presentation] Enzyme-treated asparagus extract attenuates hydrogen peroxide-induced matrix metalloproteinase-9 expression in murine dermal fibroblast L929 (2015)
  • Author(s): Shirato K, Takanari J, Ogasawara J, Sakurai T, Ishibashi Y, Imaizymi K, Ohno H, Kizaki T
  • Organizer: The 23rd International Congress on Nutrition and Integrative Medicine (ICNIM 2015)
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2015-07-25
  • Int'l Joint Research
• [Presentation] 富士登山に対する酸化ストレスセンサーの変動 (2015)
  • Author(s): 西尾聖剛、笹尾真美、白土 健、小笠原準悦、櫻井拓也、木﨑節子、長澤純一
  • Organizer: 第23回日本運動生理学会大会
  • Place of Presentation: 東京
  • Year and Date: 2015-07-25
• [Presentation] 運動トレーニングは脂肪組織のTGF-β-TIMP1経路を減弱させる (2015)
  • Author(s): 櫻井拓也、小笠原準悦、白土 健、石橋義永、井澤鉄也、大野秀樹、木崎節子
  • Organizer: 第164回日本体力医学会関東地方会
  • Place of Presentation: 横浜
  • Year and Date: 2015-07-11
• [Presentation] Enzyme-treated asparagus extract (ETAS) induced heat shock protein 70 expression and attenuates stress (2015)
  • Author(s): Ogasawara J, Shirato K, Sakurai T, Ohno H, Kizaki T
  • Organizer: The 12th Asian Congress of Nutrition (ACN 2015)
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2015-05-14
  • Int'l Joint Research / Invited
• [Presentation] 脂肪細胞の糖取り込みを抑制するTGF-β-TIMP1経路は運動によって減弱される. (2015)
  • Author(s): 櫻井拓也、小笠原準悦、白土健、石橋義永、井澤鉄也、大石修司、芳賀脩光、大野秀樹、木崎節子
  • Organizer: 第85回日本衛生学会学術総会
  • Place of Presentation: 和歌山県民文化会館、ホテルアバローム紀の国（和歌山市）
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] ブライト脂肪細胞の形成を修飾する持久的走運動トレーニングの効果. (2015)
  • Author(s): 小笠原準悦、櫻井拓也、白土健、石橋義永、井澤鉄也、大石修司、芳賀脩光、大野秀樹、木崎節子
  • Organizer: 第85回日本衛生学会学術総会
  • Place of Presentation: 和歌山県民文化会館、ホテルアバローム紀の国（和歌山市）
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] 高グルコースによるマクロファージ炎症反応の亢進における時計遺伝子Rev-erbaの役割. (2015)
  • Author(s): 白土健、櫻井拓也、小笠原準悦、石橋義永、佐藤章悟、今泉和彦、大野秀樹、木崎節子
  • Organizer: 第85回日本衛生学会学術総会
  • Place of Presentation: 和歌山県民文化会館、ホテルアバローム紀の国（和歌山市）
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] 高グルコース培養によるマクロファージの時計遺伝子Rev-erbαの発現変化とその生理的役割. (2014)
  • Author(s): 白土健、櫻井拓也、小笠原準悦、木本紀代子、高橋和人、住谷由計、石田均、大野秀樹、木﨑節子
  • Organizer: 第43回杏林医学会総会
  • Place of Presentation: 杏林大学（東京都三鷹市）
  • Year and Date: 2014-11-15
• [Presentation] マクロファージ時計遺伝子Rev-erbaの発現に及ぼす高血糖の影響. (2014)
  • Author(s): 白土健、櫻井拓也、小笠原準悦、佐藤章悟、今泉和彦、大野秀樹、木﨑節子
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 国立京都国際会館、グランドプリンスホテル京都（京都市）
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] 運動によって減少するTGF-β-TIMP1経路は脂肪細胞の糖取り込みに関与する. (2014)
  • Author(s): 櫻井拓也、小笠原準悦、白土健、石橋義永、井澤鉄也、大野秀樹、木崎節子
  • Organizer: 第69回日本体力医学会大会
  • Place of Presentation: 長崎大学文教キャンパス（長崎市）
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] 走運動トレーニングはブライト脂肪細胞の形成を促進するか. (2014)
  • Author(s): 小笠原準悦、櫻井拓也、白土健、長澤純一、井澤鉄也、大野秀樹、木崎節子
  • Organizer: 第69回日本体力医学会大会
  • Place of Presentation: 長崎大学文教キャンパス（長崎市）
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] 脂肪細胞の分化及び脂肪滴形成に及ぼすメラトニンの影響. (2014)
  • Author(s): 田中剛貴、加藤久詞、柴原拓哉、高倉久志、増田慎也、稗田睦子、白土健、小笠原準悦、櫻井拓也、木﨑節子、大野秀樹、井澤鉄也
  • Organizer: 第69回日本体力医学会大会
  • Place of Presentation: 長崎大学文教キャンパス（長崎市）
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] 時計遺伝子の発現リズムに合わせたイソプロテレノール刺激が脂肪分解反応に及ぼす影響. (2014)
  • Author(s): 加藤久詞、柴原拓哉、田中剛貴、増田慎也、高倉久志、稗田睦子、白土健、小笠原準悦、櫻井拓也、木﨑節子、大野秀樹、井澤鉄也
  • Organizer: 第69回日本体力医学会大会
  • Place of Presentation: 長崎大学文教キャンパス（長崎市）
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] 運動トレーニングが脂肪組織のホメオテイック遺伝子と骨形成タンンパク質に及ぼす影響. (2014)
  • Author(s): 柴原拓哉、加藤久詞、田中剛貴、増田慎也、高倉久志、稗田睦子、白土健、小笠原準悦、櫻井拓也、木﨑節子、大野秀樹、井澤鉄也
  • Organizer: 第69回日本体力医学会大会
  • Place of Presentation: 長崎大学文教キャンパス（長崎市）
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] ETAS, an enzyme-treated asparagus extract, has the ability to enhance both the differentaion and the neurite outgrowth in PC12 cells. (2014)
  • Author(s): Ogsawara J, Takanari J, Sakurai T, Shirato K, Ishibashi Y, Nagasawa J, Izawa T, Ohno H & Kizaki T
  • Organizer: The 22nd International Congress on Nutrition and Integrative Medicine
  • Place of Presentation: Hotel Royton Sapporo（Sapporo, Hokkaido）
  • Year and Date: 2014-07-26 – 2014-07-27
• [Presentation] マクロファージ炎症性応答に及ぼすグルコサミンの効果とメカニズム. (2014)
  • Author(s): 白土健、木崎節子、櫻井拓也、小笠原準悦、大野秀樹、今泉和彦
  • Organizer: 第161回日本体力医学会関東地方会
  • Place of Presentation: 女子栄養大学（坂戸市）
  • Year and Date: 2014-07-26
• [Presentation] 運動は肥満による脂肪組織の線維化関連因子の発現増加を減弱させる. (2014)
  • Author(s): 櫻井拓也、小笠原準悦、木崎節子、白土健、石橋義永、斎藤大蔵、大石修司、芳賀脩光、鈴木健二、大野秀樹
  • Organizer: 第84回日本衛生学会学術総会
  • Place of Presentation: 岡山コンベンションセンター、岡山国際交流センター（岡山市）
  • Year and Date: 2014-05-25 – 2014-05-27
• [Presentation] アスパラガス茎熱水抽出物（ETAS）はアミロイドβによる細胞障害性を抑制する. (2014)
  • Author(s): 小笠原準悦、伊藤知洋、高成準、三浦健人、櫻井拓也、井澤鉄也、中野法彦、長澤純一、木崎節子、大野秀樹
  • Organizer: 第84回日本衛生学会学術総会
  • Place of Presentation: 岡山コンベンションセンター、岡山国際交流センター（岡山市）
  • Year and Date: 2014-05-25 – 2014-05-27
• [Book] 体育の科学 (2016)
  • Author(s): 小笠原準悦
  • Total Pages: 80
  • Publisher: 杏林書院
• [Book] ニュー運動生理学(Ⅱ) (2015)
  • Author(s): 小笠原準悦，井澤鉄也，大野秀樹
  • Total Pages: 414
  • Publisher: 真興交易医書出版部
• [Book] Proceeding 22th International Congress on Nutrition and Integrative Medicine (2014)
  • Author(s): Ogsawara J, Takanari J, Sakurai T, Shirato K, Ishibashi Y, Nagasawa J, Izawa T, Ohno H & Kizaki T
  • Total Pages: 241
  • Publisher: AHCC Research Association