Effect of smoking on alveolar macrophage and pathogenesis of allergy
| Project/Area Number |
26350852
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Kyoto Sangyo University |
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Principal Investigator |
TAKEUCHI Minoru 京都産業大学, 総合生命科学部, 教授 (70257773)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 喫煙 / 肺胞マクロファージ / アレルギー / スギ花粉 / サイトカイン / 好中球 / 細胞表面分子 / 異物認識レセプター |
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| Outline of Final Research Achievements |
Cryptomeria Japonica pollen (CJp) is known as an allergen but not cleared to innate immunity in the lung. We reported that cigarette smoke (CS) inhibited immune functions of alveolar macrophage (AM). CJp and CS are inhaled into the lung and contact with AM. However, it is not fully understood whether CJp and CS affect to AM and neutrophils (Neu) infiltration to the lung. Therefore, we investigated the effect of CJp and CS on AM and Neu in the lung. The induced Neu to the lung by the both of increased mRNA expressions of these cytokines and chemotactic activity of CJp caused lung inflammation, and CS inhibited the influx to alveolar space in the lung of Neu and Neu stay to interstitial tissue in the lung by these functional suppressions of Neu and AM. These results suggest that CS may inhibit secondly immune response in the lung and exacereblate allergy inflammation in the lung.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Aerosol droplet delivery of mesoporous silica nanoparticles : A strategy for respiratory-based therapeutics.2015
Author(s)
Xueting Lia, Min Xue, Otto G Raabe, Holly L Aaron, Ellen A Eisen, James E Evans, Fred A Hayes, Sumire Inaga, Abderrahmane Tagmout, Minoru Takeuchi, Chris Vulpe, Jeffrey I Zink, Subhash H Risbud, Kent E Pinkerton.
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Journal Title
Nanomedicine
Volume: 11
Pages: 1377-1385
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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