Establishment of non-invasive pathology evaluation for nonalcoholic fatty liver disease using functional imaging

• Project/Area Number: 26350882
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: University of Tsukuba
• Principal Investigator: ISOBE Tomonori 筑波大学, 医学医療系, 教授 (70383643)
• Co-Investigator(Kenkyū-buntansha): 蕨 栄治 筑波大学, 医学医療系, 講師 (70396612) ; 正田 純一 筑波大学, 医学医療系, 教授 (90241827) ; 岡本 嘉一 筑波大学, 医学医療系, 講師 (90420083)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 生活習慣病 / 非アルコール性脂肪性肝疾患（NAFLD） / MRI / MRS / 超音波 / 非アルコール性脂肪性肝疾患

Outline of Final Research Achievements

Nonalcoholic fatty liver disease (NAFLD) is divided into two types: simple fatty liver and Non-alcoholic steatohepatitis. Pathology evaluation for NAFLD has been mainly performed by liver biopsy, blood test and form information of diagnostic imaging. In this study, an objective diagnostic index was established by functional imaging information from a point of view of a relationship to pathology. Moreover, a new method was proposed for the evaluation using functional information of the liver and the skeletal muscle which control glycolipid metabolism. This method is our original and not has been presented in previous studies.

Research Products

• [Journal Article] Effect of biological factors on successful measurements with skeletal-muscle 1H-MRS (2016)
  • Author(s): Isobe T, Okamoto Y, Hirano Y, Ando H, Takada K, Sato E, Shinoda K, Tadano K, Takei H, Kamizawa S, Mori Y, Suzuki H
  • Journal Title: Journal of Therapeutics and Clinical Risk Management Volume: 20 Pages: 1133-1137
  • DOI: 10.2147/tcrm.s84371
  • NAID: 120007129513
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] NAFLD診断における肝の脂肪量と線維化の評価 (2016)
  • Author(s): 磯辺智範, 岡本嘉一, 平野雄二, 正田純一
  • Journal Title: 月間インナービジョン Volume: 31（6）（通巻363号） Pages: 102-103
• [Journal Article] MRSの基礎から臨床まで (2016)
  • Author(s): 磯辺智範, 山本哲哉, 阿久津 博義, 佐藤英介, 只野喜一, 増本智彦, 榮 武二, 松村 明
  • Journal Title: 医学物理 Volume: 36 Pages: 85-91
  • NAID: 130005312335
• [Journal Article] 拡散テンソル画像の基本原理と画像解析 (2016)
  • Author(s): 佐藤英介, 磯辺智範, 山本哲哉, 松村 明
  • Journal Title: 医学物理 Volume: 36 Pages: 97-102
  • NAID: 130005312334
• [Journal Article] Influence of echo time in quantitative proton MR spectroscopy using LCModel (2015)
  • Author(s): Yamamoto T, Isobe T, Akutsu H, Masumoto T, Ando H, Sato E, Takada K, Anno I, Matsumura A
  • Journal Title: Magn Reson Imaging Volume: 33 Pages: 644-648
  • Peer Reviewed / Open Access
• [Journal Article] Acceleration training for managing nonalcoholic fatty liver disease: a pilot study (2014)
  • Author(s): Oh S, Shida T, Sawai A, Maruyama T, Eguchi K, Isobe T, Okamoto Y, Someya N, Tanaka K, Arai E, Tozawa A, Shoda J
  • Journal Title: Therapeutics and Clinical Risk Management Volume: 10 Pages: 925-936
  • DOI: 10.2147/tcrm.s68322
  • Peer Reviewed
• [Journal Article] Changes in diffusion tensor imaging (DTI) eigenvalues of skeletal muscle due to hybrid exercise training Magnetic Resonance Imaging. (2014)
  • Author(s): Okamoto Y, Kemp GJ, Isobe T, Sato E, Hirano Y, Shoda J, Minami M.
  • Journal Title: Magnetic Resonance Imaging 2014, Volume: 32 Issue: 10 Pages: 1297-1300
  • DOI: 10.1016/j.mri.2014.07.002
  • Peer Reviewed
• [Journal Article] 骨格筋のMRI (2014)
  • Author(s): 岡本嘉一, 磯辺智範, 平野雄二
  • Journal Title: 映像情報メディカル Volume: 46 Pages: 71-78
• [Presentation] Proton MRSを用いた髄液内乳酸濃度の非侵襲的測定法の確立 (2017)
  • Author(s): 磯辺智範, 只野喜一, 平野雄二, 高倉 有, 佐藤英介, 増本智彦, 榮 武二
  • Organizer: 日本放射線技術学会第63回関東支部研究発表大会
  • Place of Presentation: 栃木県総合文化センター（栃木県宇都宮市）
  • Year and Date: 2017-01-28
• [Presentation] Diffusion-weighted imaging using Local Excitation Method to Be Successful Assessment of Myometrial Invasion by Endometrial Carcinoma (2016)
  • Author(s): Ando H, Matumoto K, Takehara H, Isobe T, Sakae T, Masuda Y
  • Organizer: 第72回日本放射線技術学会総会学術大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-04-14
• [Presentation] 非アルコール性脂肪性肝疾患における骨格筋の異常 (2016)
  • Author(s): 志田隆史, 丸山 剛, 呉 世昶, 秋山 健太郎, 磯辺智範, 平野雄二, 岡本嘉一, 正田純一
  • Organizer: 第6回肥満と消化器疾患研究会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
• [Presentation] 脂肪性肝疾患の病態評価におけるMRSおよびT1rhoの有用性の検討 (2015)
  • Author(s): 磯辺智範，高倉 有，平野雄二，蘇 リナ，志田隆史，佐藤英介，只野喜一，岡本嘉一，正田純一
  • Organizer: 日本放射線技術学会第62回関東支部研究発表大会
  • Place of Presentation: ホテルメトロポリタン長野（長野）
  • Year and Date: 2015-12-12
• [Presentation] NAFLDの診断におけるT1rhoの臨床的有用性の検討 (2015)
  • Author(s): 磯辺 智範，蘇 リナ，岡本 嘉一，平野雄二，高倉 有，佐藤英介，正田純一
  • Organizer: 第43回日本磁気共鳴医学会大会
  • Place of Presentation: 東京ドームホテル（東京）
  • Year and Date: 2015-09-10
• [Presentation] 筋肉トレーニングによる骨格筋細胞内拡散変化の追跡 (2014)
  • Author(s): 岡本嘉一 磯辺智範 平野雄二 正田純一 南 学
  • Organizer: 第42回日本磁気共鳴医学会
  • Place of Presentation: 京都
  • Year and Date: 2014-09-18 – 2014-09-20
• [Presentation] Non-Invasive Assessment of Ectopic Fat in Non-Alcoholic Fatty Liver Disease Using 1H-MRS (2014)
  • Author(s): Isobe T, Okamoto Y, Hirano Y, Sihda T, Sato E, Shoda J
  • Organizer: The Section for Magnetic Resonance Technologists（SMRT）23st Annual Meeting
  • Place of Presentation: Milano, Italy
  • Year and Date: 2014-05-10 – 2014-05-12
• [Book] 診療画像技術学IIb MRI (2016)
  • Author(s): 磯辺智範
  • Total Pages: 255
  • Publisher: 医療科学社
• [Book] 医学のあゆみ 非アルコール性脂肪性肝疾患のあらたな非侵襲的評価ツール： MRSとCAP (2015)
  • Author(s): 磯辺智範, 正田純一
  • Total Pages: 70
  • Publisher: 医歯薬出版株式会社