| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
We started measurements of waist circumference (WC), visceral fat, and carotid ultrasonography from 2004, in the vanguard of Japanese medical checkup centers, and accumulated data over 10 years. Cross-sectional analyses revealed accumulation of visceral fat in female smokers, and associations between smoking and novel serum marker FGF21 and α-klotho. Not only smoking but short sleeping hours and psychological stress was associated with serum α-klotho. Longitudinal analyses revealed strong association of 10 years-changes in BMI or WC with 10 years-changes in risk factors. Smoking cessation did not increase BMI or WC and was considered a useful interventional method for preventing risk factors. In addition, improvement of sleep may be a useful interventional target.
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