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Assessment of new serum markers and web-based questionnaires in the prediction of lifestyle-related disease

Research Project

Project/Area Number 26350888
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionOsaka University

Principal Investigator

NISHIDA MAKOTO  大阪大学, 保健センター, 准教授 (00379273)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords内科 / 生活習慣病 / 内臓脂肪 / 健康診断 / 生活習慣病リスク / 血清マーカー / 動脈硬化リスク / 頸動脈エコー
Outline of Final Research Achievements

We started measurements of waist circumference (WC), visceral fat, and carotid ultrasonography from 2004, in the vanguard of Japanese medical checkup centers, and accumulated data over 10 years. Cross-sectional analyses revealed accumulation of visceral fat in female smokers, and associations between smoking and novel serum marker FGF21 and α-klotho. Not only smoking but short sleeping hours and psychological stress was associated with serum α-klotho. Longitudinal analyses revealed strong association of 10 years-changes in BMI or WC with 10 years-changes in risk factors. Smoking cessation did not increase BMI or WC and was considered a useful interventional method for preventing risk factors. In addition, improvement of sleep may be a useful interventional target.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (14 results)

All 2017 2016 2015 2014

All Journal Article (6 results) (of which Peer Reviewed: 5 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (8 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Association between N-terminal pro-brain natriuretic peptide and adiponectin in healthy Japanese men.2016

    • Author(s)
      Nakanishi K, Nishida M, Yamamoto R, Koseki M, Moriyama T, Yamauchi-Takihara K.
    • Journal Title

      Clin Chim Acta

      Volume: 460 Pages: 138-141

    • DOI

      10.1016/j.cca.2016.06.029

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 敷地内全面禁煙に向けての取り組みとその効果について2016

    • Author(s)
      石山 奈緒美(大阪大学保健センター), 梅野 有希, 川村 淳子, 明石 美智子, 中西 香織, 熊谷 一代, 村井 教子, 姫ヶ迫 由美, 小関 正博, 山本 陵平, 西田 誠, 守山 敏樹, 瀧原 圭子
    • Journal Title

      CAMPUS HEALTH

      Volume: 53 Pages: 166-168

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Klotho-related molecules upregulated by smoking habit in apparently healthy men: A cross sectional study.2015

    • Author(s)
      K. Nakanishi, M. Nishida, M. Harada, T. Ohama, N. Kawada, M. Murakami, T. Moriyama, K. Yamauchi-Takihara.
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 14230-14230

    • DOI

      10.1038/srep14230

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 青年期における血圧と肥満度の関連性への性差の影響 大阪大学学生健康診断データより2015

    • Author(s)
      川田 典孝, 川村 淳子, 村井 教子, 中西 香織, 大濱 透, 西田 誠, 守山 敏樹, 瀧原 圭子
    • Journal Title

      CAMPUS HEALTH

      Volume: 52 Pages: 279-281

    • Related Report
      2015 Research-status Report
  • [Journal Article] Reference Interval for the Apolipoprotein B-48 Concentration in Healthy Japanese Individuals2014

    • Author(s)
      Masuda D, Nishida M, Arai T, Hanada H, Yoshida H, Yamauchi-Takihara K, Moriyama T, Tada N, Yamashita S.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 21 Issue: 6 Pages: 618-627

    • DOI

      10.5551/jat.22558

    • NAID

      130004444752

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Smoking Associates With Visceral Fat Accumulation Especially in Women2014

    • Author(s)
      Nakanishi K, Nishida M, Ohama T, Moriyama T, Yamauchi-Takihara K.
    • Journal Title

      Circulation Journal

      Volume: 78 Issue: 5 Pages: 1259-1263

    • DOI

      10.1253/circj.CJ-13-1134

    • NAID

      130003391073

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Association of Cardiovascular Risk Factors and Life Style with the Changes of Waist Circumference ― 10 Years Follow-up ―2017

    • Author(s)
      Makoto Nishida, Kaori Nakanishi, Masahiro, Koseki, Keiko Takihara
    • Organizer
      第81 回日本循環器学会学術集会
    • Place of Presentation
      石川県立音楽堂ほか(金沢市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] The association between N-terminal pro-brain natriuretic peptide and adiponectin in healthy subjects2016

    • Author(s)
      Kaori Nakanishi, Makoto Nishida, Masahiro Koseki, Keiko Yamauchi-Takihara
    • Organizer
      第33回国際心臓研究学会日本部会
    • Place of Presentation
      東京コンベンションホール(東京都)
    • Year and Date
      2016-12-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 喫煙による老化促進におけるクロトー関連分子の関与について2016

    • Author(s)
      中西香織, 西田誠, 瀧原圭子
    • Organizer
      第20回日本適応医学会学術集会
    • Place of Presentation
      東京コンベンションホール(東京都)
    • Year and Date
      2016-12-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 10年間のBMI・腹囲増減に伴う健康障害と生活習慣の関連2016

    • Author(s)
      梅野 有希, 西田 誠, 川村 淳子, 村井 教子, 熊谷 一代, 中西 香織, 小関 正博, 山本 陵平, 守山 敏樹, 瀧原 圭子
    • Organizer
      第54回全国大学保健管理研究集会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2016-10-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] Smoking Upregulates The Serum Levels of Klotho-Related Molecules2016

    • Author(s)
      Kaori Nakanishi, Makoto Nishida, Masaaki Murakami, Toshiki Moriyama, Keiko Yamauchi-Takihara
    • Organizer
      ATS 2016 International Conference
    • Place of Presentation
      Moscone Convention Center (San Francisco, USA)
    • Year and Date
      2016-05-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Smoking Affects the Associations of Klotho-related Molecules, FGF-21 and Klotho, with Metabolic Disorders and Anti-inflammatory Network2016

    • Author(s)
      Makoto Nishida, Kaori Nakanishi, Masahiro Koseki, Keiko Takihara
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台国際センターほか(仙台市)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 中高年男性における男性ホルモンとメタボリック症候群の縦断的研究2016

    • Author(s)
      宮川 康, 上田 倫央, 惣田 哲次, 竹澤 健太郎, 福原 慎一郎, 木内 寛, 西田 誠, 守山 敏樹, 瀧原 圭子, 辻村 晃, 野々村 祝夫
    • Organizer
      第20 回日本生殖内分泌学会学術集会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2016-01-09
    • Related Report
      2015 Research-status Report
  • [Presentation] ジュース摂取量は蛋白尿の予測因子である2015

    • Author(s)
      山本 陵平, 守山 敏樹, 川村 淳子, 小寺 幸江, 明石 美智子, 中西 香織, 小関 正博, 西田 誠, 水田 一郎, 工藤 喬, 瀧原 圭子
    • Organizer
      第53回全国大学保健管理研究集会
    • Place of Presentation
      盛岡市民文化ホール(盛岡市)
    • Year and Date
      2015-09-09
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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