| Project/Area Number |
26350894
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
徳村 彰 安田女子大学, 薬学部, 教授 (00035560)
宇山 徹 香川大学, 医学部, 助教 (30457337)
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| Co-Investigator(Renkei-kenkyūsha) |
UEDA Natsuo 香川大学, 医学部, 教授 (20193807)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 脂質メディエーター / リン脂質 / カルシウム / 酵素 / リゾホスファチジン酸 / ホスホリパーゼ / 肥満 / N-アシルエタノールアミン / 脂質生化学 / 生活習慣病 |
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| Outline of Final Research Achievements |
Fatty acyl amides (N-acylethanolamines) are endogenous lipids showing a variety of biological actions including appetite suppression and lipolysis, and are considered to negatively regulate obesity. In the present study, we found that two members of the glycerophosphodiesterase (GDE) family, GDE4 and GDE7, function as novel lysophospholipase D-type enzymes hydrolyzing precursor lysophospholipids to form fatty acyl amides. This results suggested new targets for novel anti-obesity drugs.
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