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The relationship between exercise intensity, time, dehydration and thrombus formation mechanism and the influence of aging on that relationship.

Research Project

Project/Area Number 26350900
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionNara Medical University

Principal Investigator

Ishizashi Hiromichi  奈良県立医科大学, 医学部, 教育教授 (50260807)

Co-Investigator(Kenkyū-buntansha) 井上 芳光  大阪国際大学, 人間科学部, 教授 (70144566)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords運動強度 / 運動時間 / 脱水率 / 血栓形成 / VWF / ADAMTS13 / 加齢 / VWF / ADAMTS13 / 脱水 / 老化 / 脱水量 / フォンビルブランド因子 / 高齢者 / 若年成人
Outline of Final Research Achievements

We aimed to quantify factors influencing thrombus formation at the time of sports activities, and compared different exercise intensities, exercise times and the extent of dehydration and thrombosis. The relationship with the formation-related factor (VWF, ADAMTS 13) was also examined. As a result, thrombus formation-related factors (VWF/ADAMTS 13) indicating the tendency of thrombosis during exercise were affected by exercise intensity rather than exercise time. In addition, it was recognized that there was an "exercise intensity threshold" at which the thrombosis tendency increased significantly at about 55%VO2max. Finally, considering the relationship between the dehydration rate and thrombus formation-related factors, the difference in the dehydration rate due to the difference in ambient temperature did not affect the change in thrombus formation-related factors. These results suggest that the thrombotic tendency seen during exercise is due to exercise intensity.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report

Research Products

(11 results)

All 2017 2016 2015 2014

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Acknowledgement Compliant: 1 results) Presentation (6 results)

  • [Journal Article] Evidence for β-adrenergic modulation of sweating during incremental exercise in habitually trained males.2017

    • Author(s)
      Amano T, Shitara Y, Fujii N, Inoue Y, Kondo N.
    • Journal Title

      J Appl Physiol

      Volume: 123(1) Pages: 182-189

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Maximum rate of sweat ions reabsorption during exercise with regional differences, sex, and exercise training.2017

    • Author(s)
      Amano T, Hirose M, Konishi K, Gerrett N, Ueda H, Kondo N, Inoue Y
    • Journal Title

      Eur J Appl Physiol.

      Volume: 117 Pages: 1317-1327

    • DOI

      10.1007/s00421-017-3619-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] SEX- AND AGE-RELATED DIFFERENCES IN THERMAL ENVIRONMENT OF SUMMER DAILY LIFE2017

    • Author(s)
      井上芳光、坂東沙耶、山崎彩佳、戸谷真理子、一之瀬智子、上田博之
    • Journal Title

      Japanese Journal of Physiological Anthropology

      Volume: 22(3) Issue: 3 Pages: 135-143

    • DOI

      10.20718/jjpa.22.3_135

    • NAID

      130006189398

    • ISSN
      1342-3215, 2432-0986
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sex differences in age-related changes on peripheral warm and cold innocuous thermal sensitivity.2016

    • Author(s)
      Inoue Y, Gerrett N, Ichinose-Kuwahara T etal
    • Journal Title

      Physiol Behav

      Volume: 164 Pages: 86-92

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 夏季における高齢者の温熱的生活環境2016

    • Author(s)
      5.井上芳光,東海美咲,宮川しおり 他
    • Journal Title

      日本生理人類学会誌

      Volume: 21(1) Pages: 11-16

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 運動トレーニング者における安静温熱負荷時の発汗反応:一酸化窒素とシクロオキシゲナーゼの影響2017

    • Author(s)
      天野達郎、藤井直人、井上芳光、近藤徳彦
    • Organizer
      第72回日本体力医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高齢マラソンランナーの運動時発汗反応と身体部位差2015

    • Author(s)
      井上芳光
    • Organizer
      第70回日本体力医学会
    • Place of Presentation
      和歌山
    • Year and Date
      2015-09-19
    • Related Report
      2015 Research-status Report
  • [Presentation] エリートラグビーフットボール選手の内臓脂肪とインスリン抵抗性2015

    • Author(s)
      山下千晶、米波直子、石指宏通 他
    • Organizer
      第70回日本体力医学会
    • Place of Presentation
      和歌山
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 高齢マラソンランナーの発汗反応2015

    • Author(s)
      井上芳光、上田博之、一之瀬智子 他
    • Organizer
      第72回日本生理人類学会
    • Place of Presentation
      札幌
    • Year and Date
      2015-05-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 高齢者における血栓形成関連因子の日内・季節変動の解明2014

    • Author(s)
      石指宏通 井上芳光
    • Organizer
      第71回日本生理人類学会
    • Place of Presentation
      神戸
    • Year and Date
      2014-11-01 – 2014-11-02
    • Related Report
      2014 Research-status Report
  • [Presentation] 夏季における温熱的生活環境の性差・年齢差・季節差2014

    • Author(s)
      井上芳光 山崎彩佳 坂東沙耶 一之瀬智子 上田博之
    • Organizer
      第71回日本生理人類学会
    • Place of Presentation
      神戸
    • Year and Date
      2014-11-01 – 2014-11-02
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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