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Inhibitory effects of small amount of alcohol drinking and coffee ingestion on nonalcoholic fatty liver diseae

Research Project

Project/Area Number 26350909
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionTeikyo University

Principal Investigator

Takahashi Yoshihisa  帝京大学, 医学部, 准教授 (70334381)

Co-Investigator(Renkei-kenkyūsha) FUKUSATO Toshio  帝京大学, 医療共通教育研究センター, 教授 (50134531)
UOZAKI Hiroshi  帝京大学, 医学部, 教授 (10296246)
KUMAGAI Arisa  帝京大学, 医学部, 助教 (50596963)
Research Collaborator WATANABE Masato  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords非アルコール性脂肪性肝疾患 / 少量飲酒 / コーヒー / 飲酒 / 非アルコール性脂肪性肝炎
Outline of Final Research Achievements

In the first experiment, we examined the effects of small, middle, and large amount of alcohol administration on model mice of nonalcoholic fatty liver disease (NAFLD). As a result, small amount of ethanol administation significantly lowered liver/body weight ratio and serum AST and ALT levels, and significantly improved intalobular and portal inflammation in db/db mice that were fed a high-fat diet. In the next experiment, we examined the effects of representative ingredients of coffee on model mice of NAFLD. As a result, caffeine and chlorogenic acid significantly worsened serum ALT level in C57BL/6J mice that were fed a choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD).

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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