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Age-dependent changes of risk factors determining the survival of patients

Research Project

Project/Area Number 26350915
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionTokyo University of Technology

Principal Investigator

YAMAMOTO Yorihiro  東京工科大学, 応用生物学部, 教授 (60134475)

Co-Investigator(Kenkyū-buntansha) 加柴 美里  東京工科大学, 教養学環, 准教授 (80338186)
Co-Investigator(Renkei-kenkyūsha) KINOSHITA Kosaku  日本大学, 医学部附属板橋病院, 教授 (90260968)
SAKURAI Atsusi  日本大学病院, 准教授 (40339320)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords酸化ストレス / コエンザイムQ10 / 遊離脂肪酸 / 尿酸 / プロサポシン / 心肺停止救急患者 / ALS / 敗血症 / 活性酸素 / 遊離脂肪酸量 / 酸化型コエンザイムQ10の割合 / 血漿遊離脂肪酸量 / パルミトレイン酸 / オレイン酸 / 筋萎縮性側索硬化症(ALS / 筋萎縮性側索硬化症(ALS)
Outline of Final Research Achievements

In order to find out risk factors determining the survival of patients, we measured plasma levels of oxidized form of coenzyme Q10 (%CoQ10) and free fatty acids and their compositions in patients with ALS and PCAS. These levels were significantly different from those in healthy controls, indicating a significant increase of oxidative stress in these patients. Time course changes indicated that %CoQ10 decreased in patients who discharged in a week but remained unchanged in patients who died. Plasma level of prosaposin, a coenzyme Q10 binding and transfer protein, increased significantly, suggesting that coenzyme Q10 is necessary in a critical condition. It is interesting plasma levels of prosaposin in normal people increase with age.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (27 results)

All 2017 2016 2015 2014 2013

All Journal Article (14 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 14 results,  Open Access: 8 results,  Acknowledgement Compliant: 2 results) Presentation (13 results) (of which Int'l Joint Research: 5 results,  Invited: 6 results)

  • [Journal Article] Oxidative Stress and Abnormal Cholesterol Metabolism in Patients with Post-cardiac Arrest Syndrome2017

    • Author(s)
      Nagase M, Sakurai A, Sugita A, Matsumoto N, Kubo A, Miyazaki Y, Kinoshita K, Yamamoto Y
    • Journal Title

      J Clin Biochem Nutr

      Volume: -

    • NAID

      130006038751

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Observed adducts on positive mode direct analysis in real time mass spectrometry – Proton/ammonium adduct selectivities of 600-sample in-house chemical library2017

    • Author(s)
      Sugimura N, Furuya A, Yatsu T, Igarashi Y, Aoyama R, Izutani C, Yamamoto Y, Shibue T
    • Journal Title

      Eur J Mass Spectrom

      Volume: 21 Issue: 1 Pages: 725-730

    • DOI

      10.1177/1469066717693851

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Three-year follow-up of high-dose ubiquinol supplementation in a case of familial multiple system atrophy with compound heterozygous COQ2 mutations.2017

    • Author(s)
      Mitsui J, Koguchi K, Momose T, Takahashi M, Matsukawa T, Yasuda T, Tokushige S, Ishiura H, Goto J, Nakazaki S, Kondo T, Ito H, Yamamoto Y and Tsuji S.
    • Journal Title

      Cerebellum

      Volume: - Issue: 3 Pages: 1-9

    • DOI

      10.1007/s12311-017-0846-9

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prosaposin knockdown in Caco-2 cells decreases cellular levels of coenzyme Q10 and ATP, and results in the loss of tight junction barriers2017

    • Author(s)
      Kashiba M, Terashima M, Sagawa S, Yoshimura S, Yamamoto Y
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 60 Issue: 2 Pages: 81-85

    • DOI

      10.3164/jcbn.16-32

    • NAID

      130005398535

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The Inhibitory Effects of Anti-Oxidants on Ultraviolet-Induced Up-Regulation of the Wrinkling-Inducing Enzyme Neutral Endopeptidase in Human Fibroblasts2016

    • Author(s)
      Nakajima H, Terazawa S, Niwano T, Yamamoto Y, Imokawa G
    • Journal Title

      PLoS One

      Volume: - Issue: 9 Pages: 1-29

    • DOI

      10.1371/journal.pone.0161580

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endogenous reactive oxygen species cause astrocyte defects and neuronal dysfunctions in the hippocampus: a new model for aging brain2016

    • Author(s)
      Ishii T, Takanashi Y, Sugita K, Miyazawa M, Yanagihara R, Yasuda K, Onouchi H, Kawabe N, Nakata M, Yamamoto Y, Hartman PS, Ishii N
    • Journal Title

      Aging Cell

      Volume: - Issue: 1 Pages: 1-13

    • DOI

      10.1111/acel.12523

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Edaravone, a potent free radical scavenger, reacts with peroxynitrite to produce predominantly 4-NO-edaravone2016

    • Author(s)
      Fujisawa A, Yamamoto Y
    • Journal Title

      Redox Report

      Volume: 21 Issue: 3 Pages: 98-103

    • DOI

      10.1179/1351000215y.0000000025

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increased oxidative stress in patients with amyotrophic lateral sclerosis and the effect of edaravone administration2016

    • Author(s)
      Nagase M, YamamotoY, Miyazaki Y, Yoshino H
    • Journal Title

      Redox Report

      Volume: 21 Pages: 104-112

    • DOI

      10.1179/1351000215y.0000000026

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Randomized, double-blind, placebo-controlled pilot trial of reduced coenzyme Q10 for Parkinson’s disease2015

    • Author(s)
      Yoritaka A, Kawajiri S, Yamamoto Y, Nakahara T, Ando M, Hashimoto K, Nagase M, Saito Y, Hattori N
    • Journal Title

      Parkinsonism Relat Disord

      Volume: 21 Issue: 8 Pages: 911-916

    • DOI

      10.1016/j.parkreldis.2015.05.022

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Knockdown of the coenzyme Q synthesis gene Smed-dlp1 affects planarian regeneration and tissue homeostasis2015

    • Author(s)
      Shiobara Y, Harada C, Shiota T, Sakamoto K, Kita K, Tanaka S, Tabata K, Sekie K, Yamamoto Y, Sugiyama T
    • Journal Title

      Redox Biol

      Volume: 6 Pages: 599-606

    • DOI

      10.1016/j.redox.2015.10.004

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prosaposin regulates coenzyme Q10 levels in HepG2 cells, especially those in mitochondria2014

    • Author(s)
      Kashiba M, Oizumi M, Suzuki M, Sawamura Y, Nagashima K, Yoshimura S, Yamamoto Y.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 55 Issue: 2 Pages: 85-89

    • DOI

      10.3164/jcbn.13-106

    • NAID

      130004466769

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum coenzyme Q10 and risk of disabling dementia: the Circulatory Risk in Communities Study (CIRCS)2014

    • Author(s)
      Yamagishi K, Ikeda A, Moriyama Y, Chei C, Noda H, Umesawa M, Cui R, Nagao M, Kitamura A, Yamamoto Y, Asada T, Iso H
    • Journal Title

      Atherosclerosis

      Volume: 237 Issue: 2 Pages: 400-403

    • DOI

      10.1016/j.atherosclerosis.2014.09.017

    • NAID

      120007136193

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Roles of Oxidized Diacylglycerol for Carbon Tetrachloride-induced Liver Injury and Fibrosis in Mouse2014

    • Author(s)
      Takekoshi S, Kitatani K, Yamamoto Y
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 47 Issue: 5 Pages: 185-194

    • DOI

      10.1267/ahc.14030

    • NAID

      130004687241

    • ISSN
      0044-5991, 1347-5800
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hemodilution as a result of aggressive fluid resuscitation aggravates coagulopathy, but not survival, in a rat model of uncontrolled hemorrhagic shock2013

    • Author(s)
      Nishi K, Takasu A, Shinozaki H, Yamamoto Y, Sakamoto T
    • Journal Title

      J Trauma Acute Care Surg, g

      Volume: 74 Issue: 3 Pages: 808-12

    • DOI

      10.1097/ta.0b013e31827e1899

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Detection of hydrogen peroxide in the epidermis of patients with segmental vitiligo2016

    • Author(s)
      Yorihiro Yamamoto
    • Organizer
      Annual Meeting of the Society for Free Radical Research (Australasia)
    • Place of Presentation
      Griffith University, Gold Coast, Australia
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Coenzyme Q10 as a useful natural antioxidant2016

    • Author(s)
      Yorihiro Yamamoto
    • Organizer
      The Fifth International Conference on Cofactors
    • Place of Presentation
      Kurobe Unazuki International Hall, Unazuki, Toyama
    • Year and Date
      2016-09-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 酸化ストレスと抗酸化物質評価の医学への応用2016

    • Author(s)
      山本順寛
    • Organizer
      第69回日本酸化ストレス学会学術年会
    • Place of Presentation
      仙台国際センター,仙台,宮城
    • Year and Date
      2016-08-30
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Efficiency of singlet oxygen production from oxidized platinum nanoparticle and hydrogen peroxide2016

    • Author(s)
      Yorihiro Yamamoto
    • Organizer
      The 17th Annual Meeting of Society for Photoaging Research
    • Place of Presentation
      Translational Research Informatics Center, Kobe, Japan
    • Year and Date
      2016-08-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ペルオキシナイトライト捕捉薬としてのエダラボン2016

    • Author(s)
      山本順寛
    • Organizer
      第19回日本脳低温療法・体温管理学会
    • Place of Presentation
      ひめぎんホール,松山,愛媛
    • Year and Date
      2016-07-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] Increased oxidative stress in patients with amyotrophic lateral sclerosis and the effect of edaravone administration2015

    • Author(s)
      Yamamoto Y, Nagase M, Miyazaki Y, Yoshino H
    • Organizer
      Joint Meeting of the Societies for Free Radical Research Australasia and Japan
    • Place of Presentation
      Christchurch, New Zealand
    • Year and Date
      2015-12-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Oxidative stress and abnormal cholesterol metabolism in patients with sepsis2015

    • Author(s)
      Nagase M, Yamaguchi J, Sakurai A, Kinoshita K, Yamamoto Y
    • Organizer
      Joint Meeting of the Societies for Free Radical Research Australasia and Japan
    • Place of Presentation
      Christchurch, New Zealand
    • Year and Date
      2015-12-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] ペルオキシナイトライト消去剤としての尿酸とエダラボン2015

    • Author(s)
      山本順寛
    • Organizer
      第16回光老化研究会
    • Place of Presentation
      神戸臨床研究情報センター(兵庫県神戸市中央区)
    • Year and Date
      2015-08-22
    • Related Report
      2015 Research-status Report
  • [Presentation] コエンザイムQ (CoQ)結合蛋白質プロサポシンはミトコンドリアCoQ量とその機能を規定する2015

    • Author(s)
      加柴美里,田中裕人,ジョン・チュンユン,吉村眞一,山本順寛
    • Organizer
      第68回日本酸化ストレス学会学術集会
    • Place of Presentation
      かごしま県民交流センター(鹿児島県鹿児島市)
    • Year and Date
      2015-06-11
    • Related Report
      2015 Research-status Report
  • [Presentation] 筋萎縮性側索硬化症(ALS)における酸化ストレスとエダラボンの投与効果2015

    • Author(s)
      宮崎雄輔, 吉野 英,永瀬 翠,山本順寛
    • Organizer
      第68回日本酸化ストレス学会学術集会
    • Place of Presentation
      かごしま県民交流センター(鹿児島県鹿児島市)
    • Year and Date
      2015-06-11
    • Related Report
      2015 Research-status Report
  • [Presentation] 筋萎縮性側索硬化症(ALS)における酸化ストレスとエダラボンの投与効果2015

    • Author(s)
      永瀬翠
    • Organizer
      日本コエンザイムQ協会研究会
    • Place of Presentation
      東京工科大学(東京都八王子市)
    • Year and Date
      2015-02-03
    • Related Report
      2014 Research-status Report
  • [Presentation] 筋萎縮性側索硬化症(ALS)における酸化ストレスとエダラボンの投与効果2014

    • Author(s)
      永瀬翠
    • Organizer
      日本酸化ストレス学会
    • Place of Presentation
      同志社大学(京都府京都市)
    • Year and Date
      2014-09-04
    • Related Report
      2014 Research-status Report
  • [Presentation] 心肺停止救急患者死亡例に特徴的な血漿コレステロール低下2014

    • Author(s)
      永瀬翠
    • Organizer
      脳低温療法学会
    • Place of Presentation
      ふじのくに千本松フォーラム(静岡県沼津市)
    • Year and Date
      2014-08-01 – 2014-08-02
    • Related Report
      2014 Research-status Report
    • Invited

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Published: 2014-04-04   Modified: 2018-03-22  

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