Age-dependent changes of risk factors determining the survival of patients
| Project/Area Number |
26350915
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Tokyo University of Technology |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
加柴 美里 東京工科大学, 教養学環, 准教授 (80338186)
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| Co-Investigator(Renkei-kenkyūsha) |
KINOSHITA Kosaku 日本大学, 医学部附属板橋病院, 教授 (90260968)
SAKURAI Atsusi 日本大学病院, 准教授 (40339320)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 酸化ストレス / コエンザイムQ10 / 遊離脂肪酸 / 尿酸 / プロサポシン / 心肺停止救急患者 / ALS / 敗血症 / 活性酸素 / 遊離脂肪酸量 / 酸化型コエンザイムQ10の割合 / 血漿遊離脂肪酸量 / パルミトレイン酸 / オレイン酸 / 筋萎縮性側索硬化症（ALS / 筋萎縮性側索硬化症（ALS） |
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| Outline of Final Research Achievements |
In order to find out risk factors determining the survival of patients, we measured plasma levels of oxidized form of coenzyme Q10 (%CoQ10) and free fatty acids and their compositions in patients with ALS and PCAS. These levels were significantly different from those in healthy controls, indicating a significant increase of oxidative stress in these patients. Time course changes indicated that %CoQ10 decreased in patients who discharged in a week but remained unchanged in patients who died. Plasma level of prosaposin, a coenzyme Q10 binding and transfer protein, increased significantly, suggesting that coenzyme Q10 is necessary in a critical condition. It is interesting plasma levels of prosaposin in normal people increase with age.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Three-year follow-up of high-dose ubiquinol supplementation in a case of familial multiple system atrophy with compound heterozygous COQ2 mutations.2017
Author(s)
Mitsui J, Koguchi K, Momose T, Takahashi M, Matsukawa T, Yasuda T, Tokushige S, Ishiura H, Goto J, Nakazaki S, Kondo T, Ito H, Yamamoto Y and Tsuji S.
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Journal Title
The Cerebellum
Volume: -
Pages: 664-672
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Endogenous reactive oxygen species cause astrocyte defects and neuronal dysfunctions in the hippocampus: a new model for aging brain2016
Author(s)
Ishii T, Takanashi Y, Sugita K, Miyazawa M, Yanagihara R, Yasuda K, Onouchi H, Kawabe N, Nakata M, Yamamoto Y, Hartman PS, Ishii N
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Journal Title
Aging Cell
Volume: -
Pages: 1-13
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Randomized, double-blind, placebo-controlled pilot trial of reduced coenzyme Q10 for Parkinson’s disease2015
Author(s)
Yoritaka A, Kawajiri S, Yamamoto Y, Nakahara T, Ando M, Hashimoto K, Nagase M, Saito Y, Hattori N
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Journal Title
Parkinsonism Relat Disord
Volume: 21
Pages: 911-916
DOI
Related Report
Peer Reviewed
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[Journal Article] Serum coenzyme Q10 and risk of disabling dementia: the Circulatory Risk in Communities Study (CIRCS)2014
Author(s)
Yamagishi K, Ikeda A, Moriyama Y, Chei C, Noda H, Umesawa M, Cui R, Nagao M, Kitamura A, Yamamoto Y, Asada T, Iso H
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Journal Title
Atherosclerosis
Volume: 237
Pages: 400-403
DOI
NAID
Related Report
Peer Reviewed
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