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The typical development of the "social brain" and its alteration in autism spectrum disorders

Research Project

Project/Area Number 26350931
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Childhood science (childhood environment science)
Research InstitutionKyushu University

Principal Investigator

Yamasaki Takao  九州大学, 医学研究院, 学術研究員 (70404069)

Co-Investigator(Renkei-kenkyūsha) MAEKAWA Toshihiko  九州大学, 医学研究院, 助教 (40448436)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords自閉症スペクトラム / 社会脳 / 視覚誘発電位 / 事象関連電位
Outline of Final Research Achievements

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social communication. The aim of this study was to investigate how the ventral visual (face processing) network ("social brain") is functionally impaired in ASD. Visual evoked potentials were recorded in high-functioning ASD and typically developing (TD) adults. We used isoluminant chromatic (red/green, RG) gratings, high-contrast achromatic (black/white, BW) gratings, and face stimuli. Compared with TD controls, ASD adults exhibited longer N1 latency for RG, shorter N1 latency for BW, and shorter P1 latency, but prolonged N170 latency, for face stimuli. These findings indicate that ASD adults have enhanced fine-form processing, but impaired color processing at V1. In addition, they exhibit impaired gestalt face processing at V4. Thus, altered ventral stream function (the "social brain") may contribute to abnormal social processing in ASD.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2016 2015 2014

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results) Book (1 results)

  • [Journal Article] Enhanced fine-form perception does not contribute to gestalt face perception in autism spectrum disorder.2016

    • Author(s)
      Yamasaki, T., Maekawa, T., Miyanaga, Y., Takahashi, K., Takamiya, N., Ogata, K., & Tobimatsu, S.
    • Journal Title

      PLoS One

      Volume: 2:12 Issue: 2 Pages: 1-9

    • DOI

      10.1371/journal.pone.0170239

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 自閉症スペクトラムにおける視覚ブロッブ・インターブロッブ系の機能変化:事象関連電位を用いた研究2015

    • Author(s)
      山崎貴男、前川敏彦、宮永幸佳、高橋憲二、高宮尚美、飛松省三
    • Journal Title

      発達研究

      Volume: 29 Pages: 119-125

    • NAID

      40020512298

    • Related Report
      2015 Research-status Report
  • [Journal Article] 自閉症スペクトラムにおける視覚ブロッブ・インターブロッブ系の機能変化:事象関連電位を用いた研究2015

    • Author(s)
      山崎貴男, 前川敏彦, 宮永幸佳, 高橋憲二, 高宮尚美, 飛松省三
    • Journal Title

      発達研究

      Volume: 29

    • NAID

      40020512298

    • Related Report
      2014 Research-status Report
  • [Journal Article] 自閉症スペクトラムにおける視覚「ブロッブ障害仮説」の脳内基盤の検証:事象関連電位を用いた研究2014

    • Author(s)
      山崎貴男, 前川敏彦, 宮永幸佳, 飛松省三
    • Journal Title

      発達研究

      Volume: 28 Pages: 181-188

    • Related Report
      2014 Research-status Report
  • [Presentation] 自閉症スペクトラムにおける腹側視覚路の機能変化:VEPとERPによる検討2015

    • Author(s)
      山崎貴男、前川敏彦、高宮尚美、宮永幸佳、飛松省三
    • Organizer
      第45回日本臨床神経生理学会学術大会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2015-11-05
    • Related Report
      2015 Research-status Report
  • [Book] Clinical Applications of Magnetoencephalography2016

    • Author(s)
      Yamasaki T, Inamizu S, Goto Y, Tobimatsu S
    • Total Pages
      15
    • Publisher
      Springer Japan KK
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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