Role of intestinal flora and its related metabolites in influences of high-fat diet on intestinal diseases
| Project/Area Number |
26350960
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomolecular chemistry
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| Research Institution | Kobe University |
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Principal Investigator |
NISHIUMI SHIN 神戸大学, 医学研究科, 特命准教授 (20514706)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 高脂肪食 / メタボロミクス / 代謝物 / 腸管腫瘍 / 腸炎 / 腸内細菌 / 大腸がん / 腸疾患 |
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| Outline of Final Research Achievements |
The aim of this study was to investigate whether the successive intake of high-fat diet affects the pathogenesis of intestinal tumor and inflammatory bowel disease, and to find the candidates of intestinal flora-related metabolites that contribute to the pathogenesis of intestinal tumor and inflammatory bowel disease. As a result, I could suggest the possibility that quality of the fat affects the pathogenesis more greatly than quantity of the fat. In addition, I could clarify the possibility that sarcosine, which is one of amino acids, is one of the candidates of intestinal flora-related metabolites that contribute to the pathogenesis of intestinal tumor.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Investigations in the possibility of early detection of colorectal cancer by gas chromatography/triple-quadrupole mass spectrometry2017
Author(s)
Nishiumi S., Kobayashi T., Kawana S., Unno Y., Sakai T., Okamoto K., Yamada Y., Sudo K., Yamaji T., Saito Y., Kanemitsu Y., Tsuda Okita N., Saito H., Tsugane S., Azuma T., Ojima N., Yoshida M.
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Journal Title
Oncotarget
Volume: 8
Pages: 17115-17126
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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