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Elucidation of immunomodulatory effects of probiotic bacterial components

Research Project

Project/Area Number 26350961
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomolecular chemistry
Research InstitutionKagoshima University

Principal Investigator

HASHIMOTO Masahito  鹿児島大学, 理工学域工学系, 教授 (30333537)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords自然免疫 / 構造解析 / 酢酸菌 / リポ多糖 / 外膜小胞 / 乳酸菌 / 質量分析
Outline of Final Research Achievements

Probiotic bacteria and their bacterial components are known to keep the host homeostasis and modulate the host immune systems by interacting with intestinal immune cells. Previously we found that a traditional Japanese vinegar kurozu contains acetic acid bacterial components including lipoproteins and lipopolysaccharide, which are considered to contribute to host immune system modulation. In this study, we elucidated chemical structure of the lipopolysaccharide and found that the lipopolysaccharide exist as nano-sized vesicles in kurozu.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results) (of which Invited: 1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Characterization of a Novel d-Glycero-d-talo-oct-2-ulosonic acid-substituted Lipid A Moiety in the Lipopolysaccharide Produced by the Acetic Acid Bacterium Acetobacter pasteurianus NBRC 3283.2016

    • Author(s)
      Hashimoto, M., Ozono, M., Furuyashiki, M., Baba, R., Hashiguchi, S., Suda, Y., Fukase, K., Fujimoto, Y.
    • Journal Title

      J. Biol. Chem.

      Volume: 291 Issue: 40 Pages: 21184-21194

    • DOI

      10.1074/jbc.m116.751271

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] 酢酸菌由来リポ多糖の構造と生物活性2017

    • Author(s)
      橋本雅仁
    • Organizer
      かがわ糖質バイオフォーラム 複合糖質・糖鎖研究会
    • Place of Presentation
      e-とぴあ・かがわ BBスクエア(香川県高松市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 酢酸菌由来外膜小胞の免疫刺激能2017

    • Author(s)
      橋本雅仁、松元太一、馬場梨沙子、大薗まみ、橋口周平
    • Organizer
      第90回 日本細菌学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 酢酸菌由来リポ多糖の性質とそのリピドA構造2016

    • Author(s)
      橋本雅仁、隅田泰生、深瀬浩一、藤本ゆかり
    • Organizer
      第22回日本エンドトキシン・自然免疫研究会
    • Place of Presentation
      鹿児島大学郡元キャンパス(鹿児島県鹿児島市)
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 免疫増強剤及びその製造方法2017

    • Inventor(s)
      橋本雅仁
    • Industrial Property Rights Holder
      橋本雅仁
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-027138
    • Filing Date
      2017-02-16
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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