Elucidation of immunomodulatory effects of probiotic bacterial components
| Project/Area Number |
26350961
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomolecular chemistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 自然免疫 / 構造解析 / 酢酸菌 / リポ多糖 / 外膜小胞 / 乳酸菌 / 質量分析 |
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| Outline of Final Research Achievements |
Probiotic bacteria and their bacterial components are known to keep the host homeostasis and modulate the host immune systems by interacting with intestinal immune cells. Previously we found that a traditional Japanese vinegar kurozu contains acetic acid bacterial components including lipoproteins and lipopolysaccharide, which are considered to contribute to host immune system modulation. In this study, we elucidated chemical structure of the lipopolysaccharide and found that the lipopolysaccharide exist as nano-sized vesicles in kurozu.
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Report
(4 results)
Research Products
(5 results)
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[Journal Article] Characterization of a novel D-glycero-D-talo-oct-2-ulosonic acid-substituted lipid a moiety in the lipopolysaccharide produced by the acetic acid bacterium Acetobacter pasteurianus NBRC 3283.2016
Author(s)
Hashimoto, M., Ozono, M., Furuyashiki, M., Baba, R., Hashiguchi, S., Suda, Y., Fukase, K., Fujimoto, Y.
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Journal Title
J. Biol. Chem.
Volume: 291
Pages: 21184-21194
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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