Functional analysis of the role of hippocampal CA2 region in social behaviour and memory.
Project/Area Number |
26350979
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Basic / Social brain science
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Research Institution | Niigata University |
Principal Investigator |
Abe Manabu 新潟大学, 脳研究所, 准教授 (10334674)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 海馬 / 記憶 / 遺伝子改変マウス |
Outline of Final Research Achievements |
The aim of this study was to examine the role of CA2 neurons in memory and social behavior. The function of the hippocampal CA2 region remains largely unknown. To control neural activity by using CA2 neuron-selective gene-targeting system, we made several knock-in lines, in which Cre recombinase or tetracycline transactivator was inserted into the translational initiation site of the targeted genes (Rgs14, Amigo2, Abat and so on) in frame. Additionally, we made a new line expressing tdTomato reporter under control of Cre recombinase. The mutant lines developed in this study could be useful tools for analysis of higher brain functions.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] PKN2 is essential for mouse embryonic development and proliferation of mouse fibroblasts.2017
Author(s)
Danno S, Kubouchi K, Mehruba M, Abe M, Natsume R, Sakimura K, Eguchi S, Oka M, Hirashima M, Yasuda H, Mukai H.
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Journal Title
Genes to Cell
Volume: 22
Pages: 220-236
DOI
Related Report
Peer Reviewed
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[Journal Article] The balance between Cathepsin C and Cystatin F controls remyelination in the brain of Plp1-overexpressing mouse, a chronic demyelinating disease model2017
Author(s)
Shimizu T, Wisessmith W, Li J, Abe M, Sakimura K, Chetsawang B, Sahara Y, Tohyama K, Tanaka KF, Ikenaka K.
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Journal Title
GLIA
Volume: 65(6)
Pages: 917-930
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Transsynaptic modulation of kainate receptor functions by Clq-like proteins.2016
Author(s)
Matsuda K, Budisantoso T, Mitakidis N, Sugaya Y, Miura E, Kakegawa W, Yamasaki M, Konno K, Uchigashima M, Abe M, Watanabe I, Kano M, Watanabe M, Sakimura K, Aricescu AR, Yuzaki M
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Journal Title
Neuron
Volume: 90
Pages: 752-67
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Tt119-/- mice sperm flagella show shortening of doublet 7, reduction of doublet 5 polyglutamylation and a stall in beating.2016
Author(s)
Konno A, Ikegami K, Konishi Y, Yang HJ, Abe M, Yamazaki M, Sakimura K, Yao I, Shiba K, Inaba K, Setou M
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Journal Title
J Cell Sci.
Volume: 129
Issue: 14
Pages: 2757-2766
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] SAD-B phosphorylation of CAST controls active zone vesicle recycling for synaptic depression.2016
Author(s)
Mochida S, Hida Y, Tanifuji S, Hagiwara A, Hamada S, Abe M, Ma H, Yasumura M, Kitajima I, Sakimura K, Ohtsuka T
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Journal Title
Cell Rep.
Volume: 16
Issue: 11
Pages: 2901-13
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Involvement of Brain-Enriched Guanylate Kinase-Associated Protein (BEGAIN) in Chronic Pain after Peripheral Nerve Injury.2016
Author(s)
Katano T, Fukuda M, Furue H, Yamazaki M, Abe M, Watanabe M, Nishida K, Yao I, Yamada A, Hata Y, Okumura N, Nakazawa T, Yamamoto T, Sakimura K, Takao T, Ito S.
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Journal Title
eNeuro.
Volume: 3
Issue: 5
Pages: 0110-16
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance.2016
Author(s)
Ageta-Ishihara N, Yamazaki M, Konno K, Nakayama H, Abe M, Hashimoto K, Nishioka T, Kaibuchi K, Hattori S, Miyakawa T, Tanaka K, Huda F, Hirai H, Hashimoto K, Watanabe M, Sakimura K, Kinoshita M.
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Journal Title
Methods in Cell Biology
Volume: 6
Pages: 10090-10090
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] STAT5 Orchestrates Local Epigenetic Changes for Chromatin Accessibility and Rearrangements by Direct Binding to the TCRγ Locus.2015
Author(s)
Wagatsuma K, Tani-Ichi S, Liang B, Shitara S, Ishihara K, Abe M, Miyachi H, Kitano S, Hara T, Nanno M, Ishikawa H, Sakimura K, Nakao M, Kimura H, Ikuta K.
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Journal Title
J Immunol
Volume: 195
Pages: 1804-14
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Cdk5/p35 is required for motor coordination and cerebellar plasticity.2014
Author(s)
He X, Ishizeki M, Mita N, Wada S, Araki Y, Ogura H, Abe M, Yamazaki M, Sakimura K, Mikoshiba K, Inoue T, Ohshima T.
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Journal Title
J Neurochem
Volume: 131(1)
Pages: 53-64
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Visualization of Corticotropin-Releasing Factor Neurons by Fluorescent Proteins in the Mouse Brain and Characterization of Labeled Neurons in the Paraventricular Nucleus of the Hypothalamus.2014
Author(s)
Itoi K, Talukder AH, Fuse T, Kaneko T, Ozawa R, Sato T, Sugaya T, Uchida K, Yamazaki M, Abe M, Natsume R, Sakimura K.
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Journal Title
Endocrinology
Volume: 155(10)
Pages: 4054-4060
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] IL1RAPL1 knockout mice show learning deficiency, memory decline, hyperactivity and reduced anxiety-like behaviours.2014
Author(s)
Misato Yasumura, Tomoyuki Yoshida, Maya Yamazaki, Manabu Abe, Rie Natsume, Kouta Kanno, Takeshi Uemura, Keizo Takao, Kenji Sakimura, Takefumi Kikusui, Tsuyoshi Miyakawa, Masayoshi Mishina
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Journal Title
Sci Rep.
Volume: 4: 6613
Pages: 6613-6613
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Proteasome dysfunction induces muscle growth defects and protein aggregation2014
Author(s)
Kitajima Y, Tashiro Y, Suzuki N, Warita H, Kato M, Tateyama M, Ando R, Izumi R, Yamazaki M, Abe M, Sakimura K, Ito H, Urushitani M, Nagatomi R, Takahashi R, and Aoki M
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Journal Title
J Cell Sci
Volume: 127
Pages: 5204-17
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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