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Neural mechanism of information encoding and retrieval in the primate hippocampus.

Research Project

Project/Area Number 26350992
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Brain biometrics
Research InstitutionUniversity of Toyama

Principal Investigator

Tamura Ryoi  富山大学, 大学院医学薬学研究部(医学), 教授 (60227296)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords学習・記憶 / 霊長類 / サル / 海馬 / ニューロン活動 / 符号化・検索 / 脳波 / 周期性徐波 / 中隔核 / 場所細胞
Outline of Final Research Achievements

To clarify neural mechanism of information encoding and retrieval in the primate septo-hippocampal system, neuronal activity was recorded from the hippocampal CA1 area and medial septal nucleus in monkeys while the animal performed shuttling behavior on a linear track or while the animal was asleep. Of the 107 neurons recorded in the CA1, 17 showed location specific activity, but none of these CA1 neurons exhibited significant slow rhythmic firing. Six CA1 neurons recorded in the sleeping monkey were suppressed during REM sleep and facilitated during non-REM sleep, but none of these neurons exhibited significant slow rhythmic firing. Seven neurons were recorded in the medial septal nucleus, but again, none of these neurons exhibited significant slow rhythmic firing. These results indicate that the primate hippocampus has a different encoding and retrieval protocol of spatial information than rodents, which is independent of slow rhythmic activity.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (18 results)

All 2016 2015 2014 Other

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (10 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Remarks (2 results)

  • [Journal Article] 視線追跡装置を用いた甲状腺機能亢進症の衝動性、眼球運動速度の検討.2016

    • Author(s)
      藤田和也,三原美晴,掛上謙,石田聖朗,田村了以,林篤志
    • Journal Title

      眼科臨床紀要

      Volume: 9 Pages: 136-140

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 視線追跡装置を用いた甲状腺機能亢進症の衝動性眼球運動速度の検討.2016

    • Author(s)
      藤田和也, 三原美晴, 掛上 謙, 石田聖朗, 田村了以, 林 篤志
    • Journal Title

      眼科臨床紀要

      Volume: 9 Pages: 136-140

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Discovery of power-law growth in the self-renewal of heterogeneous glioma stem cell populations.2015

    • Author(s)
      Sugimori, M., Hayakawa, H., Boman, B.M., Fields, J.Z., Awaji, M., Kozano, H., Tamura, R., Yamamoto, S., Ogata, T., Yamada, M., Endo, S., Kurimoto, M. and Kuroda, S.
    • Journal Title

      PLoS ONE

      Volume: 10 Issue: 8 Pages: e0135760-e0135760

    • DOI

      10.1371/journal.pone.0135760

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 視線追跡装置による衝動性眼球運動速度の計測.2015

    • Author(s)
      掛上譲,藤田和也,田村了以,三原美晴
    • Journal Title

      日本視能訓練士協会誌

      Volume: 44 Pages: 177-182

    • NAID

      130005137606

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 視線追跡装置を用いた健常者と外転神経麻痺患者の衝動性眼球運動速度の比較.2015

    • Author(s)
      藤田和也, 三原美晴, 掛上 謙, 中村友子, 田村了以, 林 篤志
    • Journal Title

      眼科臨床紀要

      Volume: 8 Pages: 488-491

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of tilted orientations and face-like configurations on visual search asymmetry in macaques2014

    • Author(s)
      Nakata R, Eifuku S Tamura R
    • Journal Title

      Animal Cognition

      Volume: (In press) Issue: 1 Pages: 67-76

    • DOI

      10.1007/s10071-013-0638-7

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] サル海馬の神経活動-場所相関2016

    • Author(s)
      間 祐太朗,田村了以
    • Organizer
      第63回中部日本生理学会
    • Place of Presentation
      岡崎
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] サル海馬ニューロンの場所応答性2016

    • Author(s)
      間 祐太朗,田村了以
    • Organizer
      第25回海馬と高次脳機能学会
    • Place of Presentation
      京都
    • Year and Date
      2016-10-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] Quantifcation of fixation stability of upward gaze in myasthenia gravis by using an eye-tracking system.2016

    • Author(s)
      Mihara M, Kakeue K, Fujita K, Tamura R, Hayashi A
    • Organizer
      ARVO 2016 Annual meeting
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2016-05-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 記憶形成保持の神経機構.2015

    • Author(s)
      田村了以.
    • Organizer
      埼玉県川越市学術講演会
    • Place of Presentation
      川越
    • Year and Date
      2015-12-03
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] サル海馬CA1領域の神経活動と睡眠ステージとの相間.2015

    • Author(s)
      田村了以
    • Organizer
      第62回中部日本生理学会
    • Place of Presentation
      富山
    • Year and Date
      2015-11-13
    • Related Report
      2015 Research-status Report
  • [Presentation] 自由行動下ラットの延髄孤束核味覚ニューロンの応答性.2015

    • Author(s)
      内山久美子,上野照子,田村了以
    • Organizer
      第62回中部日本生理学会
    • Place of Presentation
      富山
    • Year and Date
      2015-11-13
    • Related Report
      2015 Research-status Report
  • [Presentation] 重症筋無力症患者に対する視線追跡装置を用いた上方注視の定量化の試み.2015

    • Author(s)
      三原美晴、藤田和也、掛上 謙、田村了以、林 篤志
    • Organizer
      第69回日本臨床眼科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report
  • [Presentation] 視線追跡装置を用いた甲状腺機能亢進症の衝動性眼球運動速度の検討.2015

    • Author(s)
      藤田 和也、三原 美晴、掛上 謙、石田 聖朗、田村 了以、林 篤志
    • Organizer
      第71回日本弱視斜視学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-03
    • Related Report
      2015 Research-status Report
  • [Presentation] サル海馬脳波の睡眠による変化2014

    • Author(s)
      田村了以,西田 悠,永福智志
    • Organizer
      第61回中部日本生理学会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-11-07 – 2014-11-08
    • Related Report
      2014 Research-status Report
  • [Presentation] サル海馬の電場電位と睡眠ステージ2014

    • Author(s)
      田村了以,西田 悠,永福智志
    • Organizer
      第23回「海馬と高次脳機能」学会
    • Place of Presentation
      金沢
    • Year and Date
      2014-10-11 – 2014-10-12
    • Related Report
      2014 Research-status Report
  • [Remarks] 富山大学・大学院医学薬学研究部(医学)統合神経科学ホームページ

    • URL

      http://www.med.u-toyama.ac.jp/ins/index-j.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 富山大学・大学院医学薬学研究部(医学)・統合神経科学ホームページ

    • URL

      http://www.med.u-toyama.ac.jp/ins/index-j.html

    • Related Report
      2015 Research-status Report 2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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