| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
A fluoride-ion-free activation for the Si-C bond has been developed to achieve the copper(I) promoted cross-coupling of aryl- and alkenyldimethylsilanes with organic halides using a double activation of the silicon atom. In this activation, the formation of cyclic silicates by intramolecular coordination of copper alkoxide facilitates the transmetallation with copper(I) and simulteniously the coordination of the oxygen atom to the silicon atom activates the Si-C bond. Thus, we have found that fluoride-free cross-coupling of aryl- and alkenyldimethylsilanes with organic halides proceeded in the presence of monocopper(I) alkoxide of ethylene glycol. In addition, we have developed a copper(I) iodide/sodium hydride/ethylene glycol system as a new activator, which promoted the reaction of aryl- and alkenyldimethylsilanes with C(sp3)-X electrophiles bearing a beta-hydrogen to produce the cross- coupling products at ambient temperature within a short period of time.
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