| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
This research representative developed that direct conversion reactions of C-H bond by using various transition metal catalysts and efficient synthetic methods of functional substances. Specifically, the following items were carried out. (1) Rh-catalyzed asymmetric C-H bond activation of benzyl ethers and its synthetic application to natural organic compounds, (2) Rh-catalyzed intramolecular hydroarylation of 1-halo-alkynes and selective synthesis of dihydroquinolines and chromenes, (3) Facile preparation of 1,2-dihydroisoquinoline by using nucleophilic addition of sulfonamide and Pd-catalyzed C-H bond activation, (4) Effective synthesis of gem-ethanopyrrolidines by using nucleophilic addition of triflamide and Pd-catalyzed C-H bond activation, (5) Simple preparation of conjugated benzofurans via nucleophilic addition of o-bromophenol followed by Pd-catalyzed double C-H bond activations, (6) Y-Mediated selective carbon chain introduction reaction to 4-position pyridine.
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