| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
In order to develop the catalytic enantioselective reactions and environmentally friendly reaction process, we designed novel chiral catalysts. In particular, we designed and synthesized an asymmetric bis(imidazoline) catalyst, developed various asymmetric synthesis reactions, investigated synthesis of biologically active substances, and analyzed reaction mechanism. As a result, we successfully synthesized optically active amines using the developed bisimidazoline-palladium catalyst based on the activation of nitriles which have not been achieved so far. It was also possible to establish the asymmetric synthesis technique in water, establish the recycling method of catalyst recovery, and developed environmentally conscious asymmetric synthesis technology.
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