| Project/Area Number |
26430049
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Hirosaki University |
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Principal Investigator |
MORI FUMIAKI 弘前大学, 医学研究科, 准教授 (60200383)
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| Co-Investigator(Kenkyū-buntansha) |
丹治 邦和 弘前大学, 医学研究科, 助教 (10271800)
若林 孝一 弘前大学, 医学研究科, 教授 (50240768)
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| Co-Investigator(Renkei-kenkyūsha) |
MIKI YASUO 弘前大学, 大学院医学研究科, 助教 (30709142)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 多系統萎縮症 / MSA / αシヌクレイノパチー / 封入体 / ストレス顆粒 / RNA / RNA結合タンパク質 / HuR / 神経変性疾患 / αシヌクレイン / オートファジー / 封入体形成 / 遺伝子改変マウス |
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| Outline of Final Research Achievements |
Stress granules are cytoplasmic messenger ribonucleoprotein particles that form dense aggregations in the cytosol composed of RNAs and RNA binding proteins that appear when translation is impaired under stress conditions. Stress granuless are thought to play an important role in the pathogenesis of neurodegenerative diseases by acting as seeds for pathological inclusions. To elucidate the significance of formation of stress granule and protein aggregates in the disease process of multiple system atrophy, we examined dynamic changes of stress granule-related proteins and protein degradation systems using tissue samples from multiple system atrophy patients and normal controls and cell and animal models for alpha-synucleinopathy. These results suggested that stress granules marker proteins and protein degradation systems may be therapeutic targets to prevent multiple system atrophy.
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