Globular glial tauopathy: investigation of the pathological features

• Project/Area Number: 26430052
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Niigata University
• Principal Investigator: TOYOSHIMA Yasuko 新潟大学, 脳研究所, 准教授 (20334675)
• Co-Investigator(Kenkyū-buntansha): 池内 健 新潟大学, 脳研究所, 教授 (20372469) ; 他田 真理 新潟大学, 脳研究所, 助教 (30646394) ; 高橋 均 新潟大学, 脳研究所, 教授 (90206839)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: タウオパチー / アストロサイト / globular glial tauopathy / オリゴマー / 神経変性疾患 / ピック病 / タウオリゴマー / 進行性核上性麻痺

Outline of Final Research Achievements

We examined the brains of GGT-type III, using an anti-tau oligomer-specific polyclonal antibody, T22 and anti-phosphorylated tau antibody, AT8. Predominant occurrence of GAIs was also confirmed with AT8 and T22. We consider that GGT are different from other 4R tauopathies not only in their pathological picture but also in their constituent tau species. It is tempting to speculate that GAIs represent a distinct, 4R tau-oligomer astrocytopathy that characterizes GGT.
We also performed a pathological and clinical investigation in 40 consecutive autopsied patients with pathological diagnoses of PSP-related disease. Unequivocal TAs were present in 22 cases, all of which were confirmed to be PSP. Such TAs were hardly observed in the other 18 cases. Cluster analysis of the distribution pattern of tau-related pathology for these 18 cases identified two subgroups, pallido-nigro-luysian atrophy (PNLA) Type 1 (n = 9) and Type 2 (n = 9).

Research Products

• [Journal Article] Globular Glial Mixed Four Repeat Tau and TDP-43 Proteinopathy with Motor Neuron Disease and Frontotemporal Dementia (2015)
  • Author(s): Takeuchi R, Toyoshima Y, Tada M, Tanaka H, Shimizu H, Shiga A, Miura T, Aoki K, Aikawa A, Ishizawa S, Ikeuchi T, Nishizawa M, Kakita A, Takahashi H
  • Journal Title: Brain Pathology Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Pathological and Clinical Spectrum of Progressive Supranuclear Palsy: with Special Reference to Astrocytic Tau Pathology (2015)
  • Author(s): Yokoyama Y, Toyoshima Y, Shiga A, Tada M, Kitamura H, Hasegawa K, Onodera O, Ikeuchi T, Someya T, Nishizawa M, Kakita A, Takahashi H
  • Journal Title: Brain Pathology Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Globular glial tauopathy: characteristic histologic features of an autopsied patient with its type II (2017)
  • Author(s): Tanaka H, Toyoshima Y, Tada M, Shimizu H, Miura T, Ikeuchi T, Takahashi H, Kakita A
  • Organizer: The 10th Congress of Asia Pacific International Academy of Pathology &
  • Place of Presentation: Bali (Indonesia)
  • Year and Date: 2017-04-24
  • Int'l Joint Research
• [Presentation] Immunohistochemical features of GGT revealed using a tau oligomer-specific antibody (2016)
  • Author(s): Tanaka H, Toyoshima Y, Tada M, Ikeuchi T, Nishizawa M, Takahashi H, Kakita A
  • Organizer: 11th European Congress of Neuropathology
  • Place of Presentation: Bordeaux （France）
  • Year and Date: 2016-07-06
  • Int'l Joint Research
• [Presentation] Immunohistochemical features of tauopathies revealed usiing a tau oligomer-specific antibody. (2016)
  • Author(s): Tanaka H, Toyoshima Y, Tada M, Shimizu H, Shiga A, Ikeuchi T, Takahashi H, Kakita A
  • Organizer: 第57回日本神経病理学会総会学術研究会
  • Place of Presentation: ホテルニューキャッスル (青森県・弘前市）
  • Year and Date: 2016-06-01
• [Presentation] Tau oligomer accumulation in patients with globular glial tauopathies -type III (2015)
  • Author(s): Toyoshima Y, Tanaka H, Takeuchi R, Shimizu H, Tada M, Shiga A, Yokota O, Kuroda S, Ikeuchi T, Kakita A, Takahashi H
  • Organizer: The 26th International Symposium on ALS/MND
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-12-10
  • Int'l Joint Research
• [Presentation] Globular glial tauopathy (type II) clinically mimicking ALS (2015)
  • Author(s): Tanaka H, Toyoshima Y, Miura T, Tada M, Shimizu H, Shiga A, Ikeuchi T, Kakita A, Takahashi H
  • Organizer: The 26th International Symposium on ALS/MND
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-12-10
  • Int'l Joint Research
• [Presentation] Globular Glial Mixed Four Repeat Tau and TDP-43 Proteinopathy with Motor Neuron Disease and Frontotemporal Dementia (2015)
  • Author(s): Takeuchi R, Toyoshima Y, Tada M, Shiga A, Miura T, Aoki K, Ikeuchi T, Nishizawa M, Kakita A, Takahashi H
  • Organizer: The 26th International Symposium on ALS/MND
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-12-10
  • Int'l Joint Research
• [Presentation] Globular glial tauopathy：蓄積タウの特徴 (2015)
  • Author(s): 豊島靖子、竹内亮子、田中英智、他田真理、清水 宏、池内 健、柿田明美、高橋 均
  • Organizer: 第56回日本神経病理学会総会学術研究会
  • Place of Presentation: 九州大学医学部百年講堂、福岡
  • Year and Date: 2015-06-03
• [Presentation] Astrocyteのタウ病理に注目したPSP関連タウオパチーの連続性について (2014)
  • Author(s): 横山裕一、豊島靖子、志賀篤、池内健、長谷川一子、柿田明美、高橋均
  • Organizer: 第５５回日本神経病理学会総会学術研究会
  • Place of Presentation: 東京 学術総合センター
  • Year and Date: 2014-06-05 – 2014-06-07
• [Presentation] 臨床的にALS-Dと診断され、特異な病理組織学的所見を呈したGlobular glial tauopathy の１例 (2014)
  • Author(s): 竹内亮子、豊島靖子、三浦健、青木賢樹、西澤正豊、柿田明美、高橋均
  • Organizer: 第５５回日本神経病理学会総会学術研究会
  • Place of Presentation: 東京 学術総合センター
  • Year and Date: 2014-06-05 – 2014-06-07