MRI imaging of the glymphatic system after focal brain injury by using 17O-H2O
| Project/Area Number |
26430071
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIOKA Yoshichika 大阪大学, 先導的学際研究機構, 教授 (00174897)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 脳脊髄液 / 脳傷害 / MRI / アルツハイマー病 / βアミロイド / アルツハイマー |
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| Outline of Final Research Achievements |
The MRI imaging of cerebrospinal and interstitial fluid dynamics (the glymphatic system) developed by using inert 17O-H2O, and the influence of focal brain injury on the glymhatic system was investigated. Even though gadolinium complex injected cerebrospinal fluid successfully imaged glymphatic flow by MRI, we failed to detect the signal from 17O-H2O injected in the same way. The enhancing efficacies measured by phantom was similar between these contrasting agents, thus 17O-H2O was likely excluded from the brain by the water exchange between cerebrospinal fluid and blood flow. We further analyzed glymphatic system by using fluorescent tracers and found that the glymhatic system broadly impaired furing the acute phase of focal cerebral injury. In addition, the increase of beta-amyloid was found in the injured hemisphere of Alzheimer model mice.
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Report
(5 results)
Research Products
(32 results)
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[Journal Article] Ganglioside contained in the neuronal tissue-enriched acidic protein of 22 kDa (NAP-22) fraction prepared from the detergent-resistant membrane microdomain of rat brain inhibits the phosphatase activity of calcineurin2015
Author(s)
Kobayashi, Y. da Silva, R. Kumanogoh, H. Miyata, S. Sato, C. Kitajima, K. Nakamura, S. Morita, M. Hayashi, F. Maekawa, S.
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Journal Title
J Neurosci Res
Volume: 93
Issue: 9
Pages: 1462-1470
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Ganglioside contained in the NAP-22 fraction prepared from the detergent-resistant membrane microdomain of rat brain inhibits the phosphatase activity of calcineurin.2015
Author(s)
Kobayashi, Y., Ronan da Silva, Kumanogoh, H., Miyata, S., Sato, C., Kitajima, K., Nakamura, S., Morita, M., Hayashi, F., Maekawa, S.
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Journal Title
J Neurosci Res
Volume: 未定
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[Presentation] Localization of neural stem cells and stroke-induced generation of new neurons and glia in the medulla oblongata2017
Author(s)
Furube, E., Hiratsuka, D., Taguchi, K., Tanaka, M., Morita, M., Miyata, S.
Organizer
第40回 日本神経科会
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