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Development of methods to provide information to assist personalized medical decision

Research Project

Project/Area Number 26430192
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical genome science
Research InstitutionKyoto University

Principal Investigator

Yamada Ryo  京都大学, 医学研究科, 教授 (50301106)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords遺伝情報 / 個別化医療 / 意思決定 / 決断理論 / ベータ分布 / 決定理論 / ベイズ統計
Outline of Final Research Achievements

In the era of personalized medicine with big information, we investigated a clinical scenario where relatively small number of patients sequentially make their own decision based on the preceding outcomes. In the scenario, individual self-decision right should be respected and also the benefit for the whole population should be increased. To achieve both, we identified that heterogeneity in decision rules among individuals is important and also optimistic expectation-based decision rule is beneficial.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2017 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Isotonic Regression Based-Method in Quantitative High-Throughput Screenings for Genotoxicity2015

    • Author(s)
      Fujii Y, Narita T, Tice RR, Takeda S, Yamada R
    • Journal Title

      Dose-response

      Volume: 1 Issue: -1 Pages: 1-20

    • DOI

      10.2203/dose-response.13-045.fujii

    • NAID

      120005668062

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] An association between anti-nuclear antibodies and HLA class II locus and heterogeneous characteristics of staining patterns: The Nagahama Study.2014

    • Author(s)
      Terao C, Ohmura K, Yamada R, Kawaguchi T, Shimizu M, Tabara Y, Takahashi M, Setoh K, Nakayama T, Kosugi S, Sekine A, Matsuda F, Tsuneyo Mimori T on behalf of the Nagahama Study Group.
    • Journal Title

      Arthritis Rheumatol.

      Volume: 66 Issue: 3_suppl Pages: 3395-403

    • DOI

      10.1177/0022034514559127

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Benefits of Heterogeneity in Decision Making When Genetic Information is limited: Optimistic Self-Determination for Precision Medicine2017

    • Author(s)
      Wang J, Yamada R
    • Organizer
      Human Genome Meeting (HGM) 2017
    • Place of Presentation
      Hotel Barcelo Sants, Barcelona,Spain
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparison of two selection strategies based on genetic information when only small sample size is available2016

    • Author(s)
      Wang J, Yamada R
    • Organizer
      The 13th International Congress of Human Genetics (ICHG)
    • Place of Presentation
      Kyoto International Conference Center,Kyoto, Japan
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of effects of self-decision selection strategies on the two-armed bandit problem to avoid wrong-side fixation2015

    • Author(s)
      Juan Wang, Ryo Yamada
    • Organizer
      2015 International Conference on Statistics and its Applications (ICSA 2015)
    • Place of Presentation
      上海
    • Year and Date
      2015-07-20
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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