| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Insulin regulates the blood glucose level by inducing glucose uptake in skeletal muscle. In this study, we aimed to reveal the role and regulatory mechanisms of the small GTPase Rac1 in insulin-dependent glucose uptake in skeletal muscle by using mouse models. We identified a novel signaling mechanism whereby the guanine nucleotide exchange factor FLJ00068 activates Rac1 downstream of phosphoinositide 3-kinase and the serine/threonine protein kinase Akt2. Furthermore, we found that the small GTPase RalA regulates glucose uptake downstream of Rac1 in skeletal muscle.
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