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Roles of transcription factor Runx 3 in ovarian follicle development and ovulation in mice

Research Project

Project/Area Number 26440167
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Morphology/Structure
Research InstitutionOkayama University

Principal Investigator

Takahashi Sumio  岡山大学, 自然科学研究科, 教授 (90144807)

Co-Investigator(Renkei-kenkyūsha) FUKAMACHI Hiroshi  東京医科歯科大学, 大学院医歯学総合研究科, 講師 (70134450)
Research Collaborator TAKEUCHI Sakae  
SAKUMA Atsuko  
TSUCHIYA Yukiko  
SAITO Yuka  
OGO Yuki  
OJIMA Fumiya  
HAYASHI Sayo  
KAYO Daichi  
MAEKAWA Tetsuya  
GU TinTin  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords排卵 / 卵巣 / ステロイホルモン / マウス / 成長因子 / 転写因子 / ステロイドホルモン
Outline of Final Research Achievements

The present study was aimed at clarifying the roles of transcription factor Runx3 in female mice. Runx3 mRNA was detected in the granulosa cells of ovaries, and in the neural cells in hypothalamic areas involved in regulation of ovulation in female mice. In Runx3 knockout female mice, hypothalamic Kisspeptin mRNA and ovarian cholesterol side-chain cleavage enzyme gene mRNA expressions were decreased. Dysfunction of hypothalamic regulatory mechanism of ovulation in Runx3 knockout female mice was demonstrated. These findings clearly suggest that Runx3 was involved in the regulation of ovarian steroid hormone production and hypothalamic ovulatory function.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (18 results)

All 2016 2015 2014

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (12 results) Book (2 results)

  • [Journal Article] Identification of striated muscle activator of Rho signaling (STARS) as a novel calmodulin target by a newly developed genome-wide screen.2016

    • Author(s)
      Yusui Furuya, Miwako Denda, Kyohei Sakane, Tomoko Ogusu, Sumio Takahashi, Masaki Magari, Naoki Kanayama, Ryo Morishita, Hiroshi Tokumitsu
    • Journal Title

      Cell calcium

      Volume: 60 Issue: 1 Pages: 32-40

    • DOI

      10.1016/j.ceca.2016.04.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of marker genes for pars tuberalis morphogenesis in chick embryo: expression of Cytokine-like 1 and Gap junction protein alpha 5 in pars tuberalis.2016

    • Author(s)
      Aizawa S, Higaki Y, Dudaui A, Nagasaka M, Takahashi S, Sakata I and Sakai T
    • Journal Title

      Cell Tissue Res.

      Volume: 366(3) Issue: 3 Pages: 721-731

    • DOI

      10.1007/s00441-016-2484-9

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Runx3 Transcription Factor Regulates Ovarian Functions and Ovulation in Female Mice2016

    • Author(s)
      Fumiya Ojima, Yuka Saito, Yukiko Tsuchiya, Daichi Kayo, Syusuke Taniuchi, Maho Ogoshi, Hiroshi Fukamachi, Sakae Takeuchi, Sumio Takahashi
    • Journal Title

      Journal of Reproduction and Development

      Volume: 未定

    • NAID

      130005431250

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] IGF-1 Gene Expression Is Differentially Regulated by Estrogen Receptors α and β in Mouse Endometrial Stromal Cells and Ovarian Granulosa cells2014

    • Author(s)
      Yuki Ogo, Shusuke Taniuchi, Fumiya Ojima, Sayo Hayashi , Itsuo Murakami, Yuka Saito, Sakae Takeuchi, Toshiyuki Kudo , and Sumio Takahashi
    • Journal Title

      Journal of Reproduction and Development

      Volume: 60 Pages: 216-223

    • NAID

      130003390836

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] activinおよびinhibin遺伝子発現制御における転写因子Runx3の役割2016

    • Author(s)
      小島史也,泰山浩司,御輿真穂,竹内栄,高橋純夫
    • Organizer
      第41回日本比較内分泌学会大会
    • Place of Presentation
      北里大学(相模原)
    • Year and Date
      2016-12-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] Expression of insulin-like growth factor 1 mRNA in granulosa cells of mouse ovarian follicular cells2015

    • Author(s)
      Hayashi, S., Ojima, F., Aizawa, S., Ogoshi, M., Takeuchi, S., Takahashi, S.
    • Organizer
      第40回日本比較内分泌学会大会
    • Place of Presentation
      広島市
    • Year and Date
      2015-12-12
    • Related Report
      2015 Research-status Report
  • [Presentation] Postnatal changes of Runx transcription factor gene expression in mouse ovaries2015

    • Author(s)
      Gu, T., Ojima, F., Aizawa, S., Ogoshi, M., Takeuchi, S., Takahshi, S.
    • Organizer
      第40回日本比較内分泌学会大会
    • Place of Presentation
      広島市
    • Year and Date
      2015-12-12
    • Related Report
      2015 Research-status Report
  • [Presentation] ニワトリIGF1転写制御におけるエストロゲン受容体アイソフォームの役割2015

    • Author(s)
      松原美咲・御輿真穂・竹内 栄・高橋純夫
    • Organizer
      日本動物学会第86回新潟大会
    • Place of Presentation
      新潟市
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 雌マウスの排卵制御機構における転写因子Runx3の役割2015

    • Author(s)
      小島史也・加用大地・松﨑佑也・御輿真穂・泰山浩司・竹内 栄・高橋純夫
    • Organizer
      日本動物学会第86回新潟大会
    • Place of Presentation
      新潟市
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report
  • [Presentation] マウス子宮内膜におけるKallikrein発現の性ステロイドホルモンによる制御2015

    • Author(s)
      徳森萌美・御輿真穂・竹内 栄・高橋純夫
    • Organizer
      日本動物学会第86回新潟大会
    • Place of Presentation
      新潟市
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report
  • [Presentation] Runx3 deletion decrease Inhbb mRNA expression in granulosa cells of immature follicles in mice2014

    • Author(s)
      小島史也・斉藤優佳・土家由紀子・御輿真穂・竹内 栄・高橋純夫
    • Organizer
      第39回日本比較内分泌学会大会
    • Place of Presentation
      基礎生物学研究所
    • Year and Date
      2014-11-08
    • Related Report
      2014 Research-status Report
  • [Presentation] 転写因子Runx3 によるマウス卵胞顆粒膜細胞機能の制御2014

    • Author(s)
      小島史也・斉藤優佳・土家由紀子・御輿真穂・竹内栄・高橋純夫
    • Organizer
      日本動物学会第85回仙台大会
    • Place of Presentation
      東北大学
    • Year and Date
      2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] マウス卵巣機能制御における転写因子Runx3の生理的役割2014

    • Author(s)
      小島史也・斉藤優佳・土家由起子・御輿真穂・竹内 栄・高橋純夫
    • Organizer
      第67回岡山実験動物研究会例会
    • Place of Presentation
      岡山大学 マスカットキューブ
    • Year and Date
      2014-07-11
    • Related Report
      2014 Research-status Report
  • [Presentation] Runx3 regulates ovulation and steroidogenesis in granulosa cells in mice2014

    • Author(s)
      Ojima F, Saito Y, Tsuchiya Y, Inagaki K, Nakamura E, Otsuka F, Ogoshi M, Takeuchi S, Takahashi S.
    • Organizer
      16th International Congress of Endocrinology
    • Place of Presentation
      Chicago
    • Year and Date
      2014-06-23
    • Related Report
      2014 Research-status Report
  • [Presentation] マウス卵胞顆粒膜細胞におけるインスリン様成長因子1 mRNAの発現2014

    • Author(s)
      林 紗代・小島史也・御輿真穂・竹内 栄・高橋純夫
    • Organizer
      第66回日本動物学会中国四国支部大会
    • Place of Presentation
      岡山理科大学
    • Year and Date
      2014-05-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 転写因子Runx3によるマウス卵胞発達の制御2014

    • Author(s)
      小島史也・斉藤優佳・土家由起子・御輿真穂・竹内 栄・高橋純夫
    • Organizer
      第66回日本動物学会中国四国支部大会
    • Place of Presentation
      岡山理科大学
    • Year and Date
      2014-05-10
    • Related Report
      2014 Research-status Report
  • [Book] 基礎生物学2016

    • Author(s)
      高橋純夫(編者),鷲谷いずみ(監修),奥田敏統,御輿真穂,角野康郎,坂本尚昭,坂本浩隆,高橋卓,高橋裕一郎,田川訓史,竹内栄,富岡憲治,峰雪芳宣,三村徹郎,山本卓
    • Total Pages
      238
    • Publisher
      培風館
    • Related Report
      2016 Annual Research Report
  • [Book] 基礎生物科学2016

    • Author(s)
      高橋純夫 その他
    • Total Pages
      225
    • Publisher
      培風館
    • Related Report
      2015 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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