| Project/Area Number |
26440169
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Morphology/Structure
|
|---|
| Research Institution | Rakuno Gakuen University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
海谷 啓之 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (40300975)
寺岡 宏樹 酪農学園大学, 獣医学群, 教授 (50222146)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
Sakai Takafumi 埼玉大学, 理工学研究科, 教授 (40235114)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | グレリン / モチリン / 消化管 / 収縮作用 / 脊椎動物 / グレリン受容体 / モチリン受容体 / 魚類 / 両生類 / 消化管運動 / 免疫組織化学 / 系統発生 / ゼブラフィッシュ / 鳥類 / 受容体 |
|---|
| Outline of Final Research Achievements |
Ghrelin and motilin are gut peptides that regulate the gastrointestinal motility of mammals and birds. The aim of this study is to clarify the function of motilin/ghrelin on gastrointestinal contractility of amphibians and fish using isolated muscle strips. Homologous ghrelin did not change the contractility of amphibians (bullfrog and Japanese fire belly newt) and fish (zebrafish) gastrointestinal tract, suggesting that the motor stimulating action of ghrelin is not conserved across vertebrates. On the other hand, motilin-mediated gastrointestinal motor regulating system is possible to present in the bullfrog and zebrafish but its physiological significance should be studied in future.
|
