Amphibian hematopoietic regulation under environmental stress
Project/Area Number |
26440171
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Morphology/Structure
|
Research Institution | Waseda University |
Principal Investigator |
Kato Takashi 早稲田大学, 教育・総合科学学術院, 教授 (80350388)
|
Research Collaborator |
KUROKI Ryota
MAEKAWA Shun
NAGASAWA Kazumichi
OKUI Takehito
TANIZAKI Yuta
SATO Kei
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 造血 / 血球 / アフリカツメガエル / ネッタイツメガエル / 環境ストレス / 造血因子 / 幹細胞 / プロテオミクス / 両生類 / イメージング / エリスロポエチン / トロンボポエチン / 赤血球 / 栓球 / 環境 |
Outline of Final Research Achievements |
To develop a better comprehension of diversity and universality in vertebrate physiological regulations, we focus on amphibian hematopoietic responses against environmental stress in African clawed frog (Xenopus laevis) and Western clawed frog (Xenopus (Silurana) tropicalis). We established an in vivo Xenopus hypoxic model that caused a pulmonary defect. This model should be vital to investigate non-hematopoietic functions of erythropoietin. In the latter model, low-temperature exposure induced pancytopenia. We revealed that one of the causes of thrombocytopenia was due to the reversible cellular adhesion between thrombocytes and the vascular wall cells.
|
Report
(4 results)
Research Products
(89 results)