Prediction of human migration by H. pylori and and evolutionary analysis of the virulence
| Project/Area Number |
26440198
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Evolutionary biology
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山岡 吉生 大分大学, 医学部, 教授 (00544248)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | Helicobacter pylori / 人類移動 / 病原性 / 系統解析 / 集団解析 / ピロリ菌 / ゲノムシーケンス / 胃がん / 胃MALTリンパ腫 / 胃炎 / 次世代シーケンサー / 胃ガン / ゲノム |
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| Outline of Final Research Achievements |
This study focused on two subjects: (1) prediction of prehistoric human migration in Asia using H. pylori, and (2) exploration of new virulence factors in H. pylori. As for the subject (1), we found that there are unique H. pylori strains in Okinawa and that divergence date of Okinawa specific strains is estimated as 20,000 to 30,000 B.C. This result suggests that human population might have reached to Ryukyu islands before Jomon era. As for the subject (2), we compared genomic sequences of H. pylori isolated from gastric cancer and MALT lymphoma patients. As the results, we found loci where amino acid frequency differs significantly between the two disease groups in major virulence genes cagA and vacA.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] The Prevalence of Helicobacter pylori Virulence Factors in Bhutan, Vietnam, and Myanmar Is Related to Gastric Cancer Incidence2015
Author(s)
Trang TT, Shiota S, Matsuda M, Binh TT, Suzuki R, Vilaichone RK, Mahachai V, Tshering L, Dung HD, Uchida T, Matsunari O, Myint T, Khien VV, Yamaoka Y.
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Journal Title
Biomed Res Int.
Volume: 830813
Pages: 1-8
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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