Theoretical and empirical studies for compensatory molecular evolution
| Project/Area Number |
26440202
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Evolutionary biology
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| Research Institution | Hokkaido University (2015-2016)
National Institute of Genetics (2014) |
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Principal Investigator |
Osada Naoki 北海道大学, 情報科学研究科, 准教授 (70416270)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 分子進化 / 集団遺伝 / 相互作用 / 共進化 / 有害変異 |
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| Outline of Final Research Achievements |
Compensatory molecular evolution refers to the process where the fixation of multiple mutation that are singly deleterious maintain organismal fitness by compensating their effects. In this research project, we mainly focus on the compensatory weak selection model, where the fixation of slightly advantageous mutations follow the fixation of slightly deleterious mutations in a variety of molecular systems, including protein-protein interaction and gene expression.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Ecological genomics in Xanthomonas: the nature of genetic adaptation with homologous recombination and host shifts2015
Author(s)
Chao-Li Huang, Pei-Hua Pu, Hao-Jen Huang, Huang-Mo Sung, Hung-Jiun Liaw, Yi-Min Chen, Chien-Ming Chen, Ming-Ban Huang, Naoki Osada, Takashi Gojobori, Tun-Wen Pai, Yu-Tin Chen*, Chi-Chuan Hwang*, Tzen-Yuh Chiang
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Journal Title
BMC Genomics
Volume: 16
Issue: 1
Pages: 188-188
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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