Polymorphisms associated with skin pigmentation in Oceaniac populations

• Project/Area Number: 26440256
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Physical anthropology
• Research Institution: The University of Tokyo
• Principal Investigator: NAKA IZUMI 東京大学, 大学院理学系研究科(理学部), 特任研究員 (10723778)
• Co-Investigator(Kenkyū-buntansha): 木村 亮介 琉球大学, 医学(系)研究科(研究院), 准教授 (00453712)
• Co-Investigator(Renkei-kenkyūsha): OHASHI Jun 東京大学, 大学院理学系研究科(理学部), 准教授 (80301141) ; YAMAGUCHI Kyoko 琉球大学, 医学(系)研究科(研究院), 研究員 (60724755)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: オセアニア / 皮膚色素 / 多型 / 皮膚色素関連遺伝子多型 / メラニン / 皮膚色素遺伝子多型 / tanning ability / 皮膚色関連多型

Outline of Final Research Achievements

In Oceania, people living in Melanesia have the darkest skin color, which is comparable to that of people living in Sub-Saharan Africa. To understand the genetic basis of skin pigmentation in Oceanian people, we investigated eight SNPs previously reported to be associated with self-reported tanning ability in European ancestry in five Oceanian populations. We calculated the tanning ability associated allele count and the tanning ability score (Σβixij) for each individual. The number of allele counts was the highest in YRI (African) and the lowest in CEU (European ancestry). Of particular interest is that the mean of the tanning ability score is lower (i.e., lighter skin color) in Tongan (Polynesian) and Rawaki (Micronesia) populations than in HapMap-JPT and CHB (East Asian) populations. A multiple regression analysis for Thai and Okinawa populations revealed that SNPs associated with melanin Index were different between populations.

Research Products

• [Presentation] Analysis of polymorphisms associated with skin pigmentation in Oceanic populations (2016)
  • Author(s): NAKA, I., NISHIDA, N., KIMURA, R., YAMAGUCHI, K., FURUSAWA, T., YAMAUCHI, T., NATSUHARA, K., ATAKA, Y., ISHIDA, T., INAOKA, T., MATSUMURA, Y., OHTSUKA, R., OHASHI, J.
  • Organizer: 第13回国際人類遺伝学会
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2016-04-03
  • Int'l Joint Research
• [Presentation] Analysis of polymorphisms associated with skin pigmentation in Oceanic populations (2016)
  • Author(s): NAKA, I., NISHIDA, N., KIMURA, R., YAMAGUCHI, K., FURUSAWA, T., YAMAUCHI, T., NATSUHARA, K., ATAKA, Y., ISHIDA, T., INAOKA, T., MATSUMURA, Y. , OHTSUKA, R., OHASHI, J.
  • Organizer: 第13回国際人類遺伝学会
  • Place of Presentation: 国立京都国際会館 （京都府・京都市）
  • Year and Date: 2016-04-03
  • Int'l Joint Research
• [Presentation] メラネシア地域集団の皮膚色素関連遺伝子多型の集団遺伝学的解析 (2015)
  • Author(s): 中伊津美、西田奈央、木村亮介、山口今日子、古澤拓郎、山内太郎、夏原和美、中澤港、安高雄治、石田貴文、稲岡司、松村康弘、大塚柳太郎、大橋順
  • Organizer: 第69回日本人類学会大会
  • Place of Presentation: 産業技術総合研究所 臨海副都心センター（東京都江東区）
  • Year and Date: 2015-10-10
• [Presentation] 中伊津美、西田奈、古澤拓郎、木村亮介、山内太郎、夏原和美、中澤港、安高雄治、石田貴文、稲岡司、松村康弘、大塚柳太郎、大橋順 (2014)
  • Author(s): オセアニア集団におけるFAAH遺伝子 Pro129Thr多型とBMIとの関連
  • Organizer: 日本人類遺伝学会大会第59回大会
  • Place of Presentation: タワーホール船堀 （東京都・江東区）
  • Year and Date: 2014-11-20 – 2014-11-22
• [Presentation] Significant association of Pro129Thr polymorphism in the fatty acid amide hydrolase (FAAH) gene with body mass index in Oceanic populations (2014)
  • Author(s): I. Naka, N. Nishida, T. Furusawa, R. Kimura, T. Yamauchi, K. Natsuhara, M. Nakazawa, Y. Ataka, T. Ishida, T. Inaoka, Y. Matsumura, R. Ohtsuka, J. Ohashi
  • Organizer: The American Society of Human Genetics
  • Place of Presentation: San Diego Convention Center (米国)
  • Year and Date: 2014-10-19 – 2014-10-22
• [Remarks] ヒトゲノム多様性研究室ホームページ
  • URL: http://www.biol.s.u-tokyo.ac.jp/users/humgendiv/index.html