| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Yeast is a microbe that contributes to bread making and alcohol fermentation. Incorporation of lactic acid and pyruvate by yeast is inhibited in a medium containing glucose. This phenomenon is partly due to glucose-induced endocytic degradation, so-called as glucose inactivation, of Jen1. It is known that glucose inactivation of Jen1 is triggered by its ubiquitination by Rsp5-Rod1 ubiquitin ligase complex. We discovered that the C-terminal 20-amino-acid region of Jen1 recognized by Rsp5-Rod1 complex and sufficient to induce glucose inactivation of transmembrane transporter.
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