| Project/Area Number |
26450141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bioorganic chemistry
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
Osada Kazumi 北海道医療大学, 歯学部, 准教授 (00382490)
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| Co-Investigator(Kenkyū-buntansha) |
柏柳 誠 旭川医科大学, 医学部, 教授 (20169436)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 恐怖誘起物質 / アルキルピラジン / 恐怖関連中枢 / カイロモン / kairomones / オオカミ尿成分 / 生物有機化学 / 農芸化学 / 行動生理学 / 神経生理学 / 恐怖誘発物質 |
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| Outline of Final Research Achievements |
The applicants indicate that P-mix ( a set of alkylpyrazine analogues which identified from wolf urine) are novel kairomones inducing fear-responses to wide range of prey animals (mouse, rat, deer). In addition, structure-activity revealed that active alkylpyrazines inducing fear-responses had methyl or ethyl group(s), and alkyl side chains consisting of four carbon atoms in total were present in the most potent analogs. Moreover, the neural projection of the P-mix stimulation to the rat brain were explored. We clarified that the P-mix but not a control fruity odor mixture increased Fos immunoreactivity of AOB, medial and central amygdala, and hypothalamus of rats. The results suggest that P-mix odor induces unlearned fear-related behaviors in rats.
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