Development of Practical Molecular Synthetic Method Based on New Fluorous Chemistry
| Project/Area Number |
26450145
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bioorganic chemistry
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| Research Institution | Meijo University |
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Principal Investigator |
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| Research Collaborator |
SHIOIRI Takayuki 名城大学, 農学部, 研究員
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | フルオラスケミストリー / 全合成 / 生物活性 / ミクスチャー合成 / エポキシ化 / 相間移動触媒 / メタセシス / フルオラス / サレン錯体 / 天然物 / フルオラスミクスチャー合成 / フルオラス Fmoc / 液相ミクスチャー合成 / テフロン / サレンMn錯体 / 共溶媒効果 / 不斉エポキシ化 |
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| Outline of Final Research Achievements |
Based on medium fluorous chemistry, we carried out research aiming at exploiting a practical technology to synthesize molecules. As a result, the following results were obtained.
1) A solid phase (teflon)-liquid phase (reaction solvent) transfer metathesis catalyst was develoipped. 2) In the asymmetric epoxidation reaction using fluorous salen Mn complex, co-solvent effect for enantioselectivity was found. 3) It was revealed that if the N-terminal of amino acid is protected by fluorous Fmoc group, the peptides can be isolated easily by just addition of water into the reaction system. 4) Total synthesis of dendroamide A and all its stereoisomers were achieved by fluorous mixture synthesis.
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Report
(5 results)
Research Products
(62 results)
