Studies of metabolic demands and de novo synthesis of dispensable amino acids
| Project/Area Number |
26450157
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Food science
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 可欠アミノ酸 / セリン合成 / 3-ホスホグリセリン酸脱水素酵素 / タンパク質栄養 / タンパク質必要量 / 組織特異的発現 / ラット / 可決アミノ酸 / 3―ホスホグリセリン酸脱水素酵素 |
|---|
| Outline of Final Research Achievements |
Serine is a typical dispensable amino acid and known essentiality of its de novo synthesis. To clarify the metabolic demand of dispensable amino and its de novo synthesis, serine concentration and expression of PHGDH, the rate limiting enzyme of serine synthesis, was determined in several tissues of rat under different nutritional conditions and diabetes. The result shows that the protein nutrition most significantly affected the serine concentrations in tissues and plasm. It is found that serine concentration of liver, intestine and muscle was significantly decreased in diabetes rat. PHGDH was demonstrated to express ubiquitously in tissues investigated and the expression in liver, intestine and muscle was changed in response to protein nutrition. However, the clear relation between the expression of PHGDH and serine concentrations of tissues was not demonstrated.
|
Report
(4 results)
Research Products
(5 results)
-
[Journal Article] Down Regulation of Asparagine Synthetase and 3-Phosphoglycerate Dehydrogenase, and the Up-Regulation of Serine Dehydratase in Rat Liver from Intake of Excess Amount of Leucine Are Not Related to Leucine-Caused Amino Acid Imbalance2015
Author(s)
Yoshimura, R., Takai, M., Namaki, H., Minami, K., Imamura, W., Kato, H., Kamei, Y., and Kanamoto, R.
-
Journal Title
Journal of Nutritional Science and Vitaminology
Volume: 61
Issue: 6
Pages: 441-448
DOI
NAID
ISSN
0301-4800, 1881-7742
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
