| Project/Area Number |
26450166
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ODA Munehiro 日本大学, 生物資源科学部, 教授 (10508691)
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| Research Collaborator |
RI Shumou
SHINOZAKI Yuko
TAKAHASHI Narumi
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 応用生物化学 / 応用酵素学 / 糖質化学 / 機能性オリゴ糖 / 微生物利用学 / タンパク質工学 / N－アセチルグルコサミン / N－アセチルスクロサミン / 腸内細菌 / 酵素利用合成 / 糖転移反応 / N-アセチルスクロサミン / プレバイオティックス / ビフィズス菌 / 糖質関連酵素 / N-アセチルグルコサミン |
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| Outline of Final Research Achievements |
We synthesized novel N-acetylglucosamine-containing oligosaccharides using several transglycosylation-catalyzing glycosidases, and evaluated their prebiotics effect.
As the results, we succeeded in the synthesis 6 kinds of the oligosaccharides using N-acetylsucrosamine as a low material. Moreover, we found that these oligosaccharides proliferated specific species of Bifidobacteria. These facts indicate the possibility that N-acetylglucosamine-containing oligosaccharides we synthesized in this study become new type of prebiotics.
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