Functional regulation of canine adipocytes through TGF-beta family signaling

Research Project

Project/Area Number	26450442
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Integrative animal science
Research Institution	Kyoto University
Principal Investigator	Funaba Masayuki 京都大学, 農学研究科, 准教授 (40238655)
Co-Investigator(Renkei-kenkyūsha)	MURAKAMI Masaru 麻布大学, 獣医学部, 教授 (80271360)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	脂肪細胞 / イヌ / TGF-βファミリー
Outline of Final Research Achievements	We evaluated SNPs on ALK3 and ALK7 genes using a total of 55 dogs of various breeds, which have been shown to relate to obesity in humans; no SNPs were detected. Treatment with TGF-β1, activin A, activin B, BMP4 or BMP7 increased expression level of adipose triglyceride lipase. TGF-β family affected cellular content of free amino acids in adipocytes. Especially, insulin-induced decrease in cellular content of arginine, glutamic acid and phenylalanine was exaggerated by TGF-β1, activin A and activin B.

Report

(4 results)