| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Enantioselective total syntheses of bioactive natural products were carried out. 1) Metachromin J and K, 2) epiliolide and its hydrate, and 3) altemicidin were chosen as target molecules because of their unique bioacitivites. In metachromin derivative synthesis, the precursor for asymmetric reaction via C-O axially chiral enolate was invesitigated. The preparation of substrate for synthesizing epiliolides through intramolecular cyclization using NHC catalyst and asymmetric aldol reaction has been accomplished. Investigation of alpha-arylation reaciton with C-N axially chiral enolate and benzyne, which is supposed as key reaction in altemicidin synthesis, resulted in giving benzocyclobutenone derivative bearing tetrasubstituted carbon in high enantioselectivity.
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