| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Toward total syntheses of bioactive meroterpenoids berkeleyones, a stereoselective method for the construction of bridged polycyclic systems by a biomimetic polycyclization reaction has been developed. A model study revealed that the desired reaction proceeded in a concerted manner upon treatment of epoxyallylsilanes with diethylaluminum chloride, leading to the regio- and stereoselective formation of bridged polycyclic compounds. The cyclization product having an oxygen functionality at C8 was successfully converted to C3-dehydrated berkeleytrione through a ring-closing metathesis reaction.
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